Journal of Immunology Research

Exploration of Novel Potential Biomarkers for Cancer Immunotherapy


Publishing date
01 Jan 2023
Status
Published
Submission deadline
09 Sep 2022

Lead Editor

1Xi’an Jiaotong University, Xi'an, China

2Sun Yat-Sen University, Guangzhou, China

3Imperial College London, London, UK


Exploration of Novel Potential Biomarkers for Cancer Immunotherapy

Description

In 2016, the American Society of Clinical Oncology (ASCO) named immunotherapy the “Advance of the Year”. Within a few years, it has revolutionized cancer therapy. Therefore, there is an increasing need to identify novel potential biomarkers for the complex responses of immune checkpoint inhibitors, which would further increase the treatment responses and prolong the survival of cancer patients. Biomarkers are biological/pathological molecules present in or produced by patients, which could be found in blood, tumor cells, or tissue at the genomic, cellular, and soluble levels. Such biomarkers come in different forms, for example, host genomic factors, serum proteins, and nucleic acids (DNA or RNA molecules) within tumor cells and their microenvironments. Ideal biomarkers could aid healthcare professionals to achieve optimal treatment goals and bring clinical benefits to patients.

In the past decade, multiple tumor biomarkers have been validated and are widely used in clinics with proven effectiveness. However, there is still a need to develop new strategies to improve the efficiency and accuracy of cancer treatments by identifying more reliable biomarkers. With the development of high-throughput sequencing technologies in proteomics and genomics, both single and multifactorial synergistic markers have been gradually explored for clinical purposes using a variety of biomarker strategies. For instance, mass spectrometry improved the diagnosis of hybrid tumors and bulk, as well as single-cell sequencing which improved our current understanding of tumor cell-specific markers used for early diagnosis. Identification of multiple immune-checkpoint markers that are critical for developing therapeutic targets for precise immune-oncology, would have a profound impact in the field of personalized medicine.

The aim of this Special Issue is to bring together original research and review articles focusing on exploring novel predictive biomarkers for cancer diagnosis and prognosis, with an emphasis on immunotherapy techniques.

Potential topics include but are not limited to the following:

  • Tumor genome and neoantigen-related biomarkers
  • Tumor immune microenvironment phenotype-associated biomarkers
  • Liquid biopsy biomarkers such as circulating tumor DNA or peripheral blood cell biomarkers
  • Biomarkers for tumor diagnosis and immunotherapy targets
  • Use of biomarkers for the assessment of prognosis of tumors
  • Biomarkers for predicting tumor recurrence and metastasis
  • Biomarkers for identification of tumor-associated cell types
  • The spatial-temporal changes and regulatory mechanisms involved with biomarkers
  • New methodologies including algorithms used for characterization of tumor biomarkers

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9782082
  • - Retraction

Retracted: Mutational Screening of Skeletal Genes in 14 Chinese Children with Osteogenesis Imperfecta Using Targeted Sequencing

Journal of Immunology Research
  • Special Issue
  • - Volume 2023
  • - Article ID 9891463
  • - Retraction

Retracted: Comparison of Outcomes between Two Surgical Techniques for Patients with Intestinal Neuronal Dysplasia

Journal of Immunology Research
  • Special Issue
  • - Volume 2023
  • - Article ID 9821965
  • - Retraction

Retracted: Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling

Journal of Immunology Research
  • Special Issue
  • - Volume 2023
  • - Article ID 5437526
  • - Research Article

Increased FOXM1 Expression was Associated with the Prognosis and the Recruitment of Neutrophils in Endometrial Cancer

Jing Chen | Pusheng Yang | ... | Yichen Feng
  • Special Issue
  • - Volume 2023
  • - Article ID 8643548
  • - Research Article

Cyr61 Mediates Angiotensin II-Induced Podocyte Apoptosis via the Upregulation of TXNIP

Jingxue Ma | Ruiying Ma | ... | Junjie Wang
  • Special Issue
  • - Volume 2023
  • - Article ID 6956038
  • - Research Article

circSPECC1 Promotes Proliferation and Migration of LNCaP Prostate Cancer Cells by Affecting Their Epithelial-Mesenchymal Transition

Fangmei Xie | Jian Shen | ... | Jinhua He
  • Special Issue
  • - Volume 2023
  • - Article ID 9011232
  • - Research Article

lncRNA HCG11 Promotes Colorectal Cancer Cell Malignant Behaviors via Sponging miR-26b-5p

Song Guo | Bingtan Song | ... | Jian Wang
  • Special Issue
  • - Volume 2023
  • - Article ID 8727884
  • - Research Article

Exosome-Associated Gene Signature for Predicting the Prognosis of Ovarian Cancer Patients

Zihan Zhu | Rui Geng | ... | Jianling Bai
  • Special Issue
  • - Volume 2023
  • - Article ID 2623317
  • - Research Article

The Expression of ARMCX1 in Gastric Cancer Contributes to Prognosis and Influences Chemotherapy

Changheng Lv | Di Yang | ... | Jingjie Zhao
  • Special Issue
  • - Volume 2022
  • - Article ID 5160705
  • - Research Article

Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosuppressive Microenvironment in Breast Cancer

Lili Wang | Shuimei Luo | ... | Xianhe Xie
Journal of Immunology Research
 Journal metrics
See full report
Acceptance rate12%
Submission to final decision122 days
Acceptance to publication24 days
CiteScore6.000
Journal Citation Indicator0.560
Impact Factor4.1
 Submit Evaluate your manuscript with the free Manuscript Language Checker

We have begun to integrate the 200+ Hindawi journals into Wiley’s journal portfolio. You can find out more about how this benefits our journal communities on our FAQ.