Lyme borreliosis is a multisystem disease with rather diverse clinical presentation. Most often skin, nervous system, and joints are affected. The disease is caused by spirochetes of the Borrelia burgdorferi sensu lato complex. Lyme borreliosis has been of great interest for researchers as well as clinicians. Although several hundred reports on Lyme borreliosis have been published during the last few years, many issues remain to be clarified including those in the field of innate and adaptive immune response to the control and eradication of B. burgdorferi infection and the management of patients.

For this special issue we invite basic scientists as well as clinicians to submit original research or review articles highlighting recent advances in pathogenesis influencing on diagnosis, management, and prevention of Lyme borreliosis. Potential topics include, but are not limited to:

• Pathogenesis of Lyme borreliosis
• Innate and adaptive immune response in Lyme borreliosis
• Influence of immune response on clinical presentation of Lyme borreliosis
• Components of immune response potentially useful as biomarkers for Lyme borreliosis
• Diagnostic and therapeutic approaches in Lyme borreliosis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: