Journal of Immunology Research

Translational Research Based on Pathogen-Derived Molecules Inducing Innate And Adaptive Immune Responses


Publishing date
01 Sep 2021
Status
Closed
Submission deadline
07 May 2021

Lead Editor

1Nanjing Medical University, Nanjing, China

2QIMR Berghofer Medical Research Institute, Brisbane, Australia

3University of Pittsburgh, Pittsburgh, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Translational Research Based on Pathogen-Derived Molecules Inducing Innate And Adaptive Immune Responses

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Translational medicine is concerned with the translation of basic research discoveries into clinical applications for the prevention, diagnosis, and treatment of human diseases. Diseases are largely regulated by the immune system, which relies on pattern recognition receptors (PRRs) such as Toll-like receptors, Scavenger receptors (SRs), as well as NOD-like receptors (NLRs). The activation of PPRs by the pathogen-associated molecular patterns (PAMPs), which are macromolecules that interact with the specific PRRs on or inside antigen presenting cells, triggers the innate immune response that is crucial to the successful induction of Th1/Th2/Th17/Treg/Tfh-phenotyped adaptive immunity. Looking for the application value of new genes, molecules, and drugs to act on immune-related diseases is critical for the development of translational medicine, and it is particularly important to explore the immunological mechanisms of such molecules and drugs.

The “hygiene hypothesis” states that the attenuated exposure to microbial components leads to an imbalance of the immune system with a predisposition to the development of allergic disorders. Epidemiological studies were conducted supporting this concept that some pathogen infections (e.g. helminth or gut microbiota), which are characterized by the induction of strong type 2 responses or regulatory T cells, correlate with a decreased prevalence of intestinal inflammatory diseases, obesity, allergic diseases, and cancer, etc. Although several pathogen-derived vaccine adjuvants have been undergoing clinical trials, identification of other new molecules, including proteins, miRNAs, lipids, glycans, as well as extracellular vesicles (EVs), derived/released from various pathogens (including parasites and microbiota) is critical for treating various diseases from the host-pathogen interaction perspective. A better understanding of these questions is important not only from a theoretical point of view but also for their therapeutic implications.

This Special Issue aims to present and discuss the advancement of pathogen-derived molecules and innovative therapies and diagnostics involving various diseases, including cancer, obesity, hepatic disease, diabetes, etc. We solicit high-quality original research articles as well as review articles focusing on the interaction between the above molecules and the immune system, as well as potential roles in the treatment of immune-related diseases.

Potential topics include but are not limited to the following:

  • New findings of pathogen-derived molecules in the immunological response
  • Potential diagnostic and prognostic markers for infectious diseases
  • Treatment of cancers, metabolic diseases, and infectious diseases based on pathogen-derived molecules
  • The potential role of extracellular vesicles (EVs) released by pathogens on the host immune system
  • Molecules acting on PRRs and the regulation of the immune response
  • Host-pathogen interaction
  • Novel approaches for pathogen-derived molecules in the regulation of inflammation

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9938397
  • - Research Article

SLC2A5 Correlated with Immune Infiltration: A Candidate Diagnostic and Prognostic Biomarker for Lung Adenocarcinoma

Lianxiang Luo | Jiating Su | ... | Hui Luo
  • Special Issue
  • - Volume 2021
  • - Article ID 8782672
  • - Review Article

The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes

Xuyang Gao | Yue Zhong | ... | Jinling Chen
  • Special Issue
  • - Volume 2021
  • - Article ID 6625551
  • - Research Article

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus

Liwen Zhang | Yu Wan | ... | Baojin Cheng
  • Special Issue
  • - Volume 2021
  • - Article ID 6657894
  • - Research Article

Analysis of Lymphocyte Subpopulations and Cytokines in COVID-19-Associated Pneumonia and Community-Acquired Pneumonia

Guohong Liu | Xianghu Jiang | ... | Haibo Xu
  • Special Issue
  • - Volume 2021
  • - Article ID 6638119
  • - Research Article

1α,25-Dihydroxyvitamin D3 Supplementation during Pregnancy Is Associated with Allergic Rhinitis in the Offspring by Modulating Immunity

Liqing Zhang | Haifeng Ni | ... | Yong Li
  • Special Issue
  • - Volume 2021
  • - Article ID 6647122
  • - Research Article

Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma

Lianxiang Luo | Yushi Zheng | ... | Hui Luo
  • Special Issue
  • - Volume 2021
  • - Article ID 6663035
  • - Review Article

Application of Bionanomaterials in Tumor Immune Microenvironment Therapy

Jiawei Wang | Yan Bao | Yandan Yao
  • Special Issue
  • - Volume 2021
  • - Article ID 6690100
  • - Research Article

High-Expressed Macrophage Scavenger Receptor 1 Predicts Severity Clinical Outcome in Transplant Patient in Idiopathic Pulmonary Fibrosis Disease

Mingfeng Zheng | Tian Tian | ... | Yong Ji
  • Special Issue
  • - Volume 2021
  • - Article ID 6647753
  • - Research Article

Club Cell Protein 16 Attenuates CD16brightCD62dim Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury

Nils Becker | Philipp Störmann | ... | Borna Relja
  • Special Issue
  • - Volume 2020
  • - Article ID 8835393
  • - Research Article

DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration

Yanni Xu | Qiongchao Jiang | ... | Baoming Luo
Journal of Immunology Research
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Acceptance rate45%
Submission to final decision61 days
Acceptance to publication37 days
CiteScore5.600
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