Journal of Immunology Research

Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation


Publishing date
20 Dec 2013
Status
Published
Submission deadline
02 Aug 2013

Lead Editor

1Department of Immunology, Faculty of Medicine, Liver Transplantation Institute, İnönü University, Malatya, Turkey

2Department of Pathology, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey

3Department of Surgery, Giessen University, Giessen, Germany

4Department of Infectious Diseases and Clinical Microbiology, İnönü University Faculty of Medicine, Malatya, Turkey

5Weizmann Institute of Science, Rehovot, Israel

6Department of of Medicine, Basic Science & Biospecimen Laboratory, Loma Linda University Cancer Center, USA


Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation

Description

The liver is the largest solid organ in the body and commands a large blood supply that is rich in bacterial products, environment toxins, and food antigens, which are repeatedly scanned by cells within the liver. In addition, the regenerative capability of liver tissue makes it unique in comparison to other internal organs. In contrast to these beneficial properties, the liver is one of the most common sites for metastatic diseases; it supports chronic viral infections caused by hepatitis B and C and can also promote tolerance against external antigens in animal models. Furthermore, interestingly, liver transplantation often requires less immunosuppression compared to kidney and other solid organ transplantations. Despite these properties, the study of liver immunology remains in its infancy, and many questions remain unanswered. Can we accept the liver as a peripheral organ of the immune system? In which cases and by what mechanism does the liver alter tolerance and immunity? What are the risks and outcomes of infections after liver transplantation? Finally, what is the role of the liver during the immunization process?

We invite authors to submit original clinical or experimental research and review articles that seek to define the relationship between the liver and the immune system during infection, malignancy, and transplantation. We are particularly interested in articles describing the role of the immune system in the liver at the molecular and cellular levels. Potential topics include, but are not limited to:

  • The liver and its role in the immune system
  • Immunopathogenesis of liver diseases
  • Viral infections and immunity in the liver
  • Hepatocellular carcinoma and the immune response
  • Metastatic liver cancer and the immune response
  • Immunotherapeutic approaches to liver diseases
  • Infection and immune suppression after liver transplantation
  • Vaccination and preventable infections in liver transplant recipients and patients with chronic hepatitis

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jir/irl/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 709126
  • - Editorial

Immune Response in the Liver under Conditions of Infection, Malignancy, and Transplantation

Basak Kayhan | Sukru Oguz Ozdamar | ... | Saied Mirshahidi
  • Special Issue
  • - Volume 2014
  • - Article ID 686879
  • - Review Article

Immune Escape Mechanisms in Colorectal Cancer Pathogenesis and Liver Metastasis

Massimo Pancione | Guido Giordano | ... | Vittorio Colantuoni
  • Special Issue
  • - Volume 2013
  • - Article ID 936063
  • - Clinical Study

Immune Response following Liver Transplantation Compared to Kidney Transplantation: Usefulness of Monitoring Peripheral Blood CD4+ Adenosine Triphosphate Activity and Cytochrome P450 3A5 Genotype Assay

Yu Nobuoka | Shugo Mizuno | ... | Shuji Isaji
  • Special Issue
  • - Volume 2013
  • - Article ID 413928
  • - Research Article

Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation

Toshiaki Nakano | Shigeru Goto | ... | Chao-Long Chen
  • Special Issue
  • - Volume 2013
  • - Article ID 342686
  • - Research Article

Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain

Oxana V. Potapova | Tatyana V. Sharkova | ... | Alexander M. Shestopalov
  • Special Issue
  • - Volume 2013
  • - Article ID 325318
  • - Review Article

Chemokines in Chronic Liver Allograft Dysfunction Pathogenesis and Potential Therapeutic Targets

Bin Liu | Jing Li | Lu-Nan Yan
  • Special Issue
  • - Volume 2013
  • - Article ID 750406
  • - Research Article

Hepatic Expression of Metallothionein I/II, Glycoprotein 96, IL-6, and TGF-β in Rat Strains with Different Susceptibilities to Experimental Autoimmune Encephalomyelitis

Tanja Grubić-Kezele | Gordana Blagojević Zagorac | ... | Biserka Radošević-Stašić
  • Special Issue
  • - Volume 2013
  • - Article ID 828201
  • - Research Article

Anti-HLA and Anti-MICA Antibodies in Liver Transplant Recipients: Effect on Long-Term Graft Survival

Michał Ciszek | Bartosz Foroncewicz | ... | Leszek Pączek
  • Special Issue
  • - Volume 2013
  • - Article ID 145725
  • - Research Article

Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population

Fengqin Miao | Hang Sun | ... | Jianqiong Zhang
  • Special Issue
  • - Volume 2013
  • - Article ID 874514
  • - Research Article

Combination of Human Leukocyte Antigen and Killer Cell Immunoglobulin-Like Receptor Genetic Background Influences the Onset Age of Hepatocellular Carcinoma in Male Patients with Hepatitis B Virus Infection

Ning Pan | Jie Qiu | ... | Jianqiong Zhang
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision105 days
Acceptance to publication37 days
CiteScore3.330
Impact Factor3.404
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