Journal of Immunology Research

Viruses and Immunity in Transplant Patients


Publishing date
21 Dec 2012
Status
Published
Submission deadline
03 Aug 2012

Lead Editor

1Virology Unit, University Hospital San Giovanni Battista di Torino, 10126 Turin, Italy

2Department of Experimental Medicine, University of Roma, Italy

3Department of Biomedicine, University of Basel, 4031 Basel, Switzerland


Viruses and Immunity in Transplant Patients

Description

Viral infections and diseases are one of the main factors influencing the outcome of solid organ and hematopoietic stem cell transplant recipients.

In the context of antirejection treatment, viral replication and progression toward disease are related to patient, virus, and graft determinants. This complex interaction is modulated by the net balance of immunosuppression and its impact on virus-specific immune response. The development of immunosuppressive agents is based on our knowledge of mechanisms of T-cell activation, thus allowing for the identification of potential new targets. Recently developed immunosuppressive agents are able to determine a deep and prolonged immunosuppression, thus being associated to a reduced incidence of rejection and, on the other hand, an increased susceptibility to infections.

The immunologic control of viral replication in the immunocompromised host involves both the innate and adaptative immune response. In particular, adaptative immune responses of B and T lymphocytes are critical in determining the risk of viral reactivation. In recent years, beside virological monitoring in the transplant setting, viroimmunological evaluation has been proposed as a useful tool for clinical and therapeutic management.

We invite authors to submit original research and review articles that aim to stimulate the continuing efforts to understand the interplay between host and viruses in the transplant setting in order to define strategies for diagnostics, monitoring, and therapeutic management in both the prophylaxis and the pre-emptive context. We are particularly interested in articles that explore aspects of antiviral immunity, methods and significance of viroimmunological monitoring, as well as relation between antirejection therapies and viral reactivation in both solid organ and hematopoietic stem cell transplant recipients. Potential topics include, but are not limited to:

  • Innate immune response to viral pathogens in transplant patients
  • Adaptative immune response to viral pathogens in transplant patients
  • Monitoring of virus-specific cellular immune response in transplant patients
  • Development of new immunosuppressive agents and their impact of virus‑specific immunity in transplant patients
  • Strategies for monitoring and diagnosing viral infections in transplant patients
  • Impact of immunosuppressive agents on virus-specific immune response

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jir/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 492352
  • - Editorial

Viruses and Immunity in Transplant Patients

Rossana Cavallo | Guido Antonelli | Hans H. Hirsch
  • Special Issue
  • - Volume 2013
  • - Article ID 890517
  • - Review Article

New Insights in Recurrent HCV Infection after Liver Transplantation

Shih-Hsien Hsu | Ming-Lun Yeh | Shen-Nien Wang
  • Special Issue
  • - Volume 2013
  • - Article ID 626823
  • - Research Article

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression

Michela Cioni | Christian Mittelholzer | ... | Hans H. Hirsch
  • Special Issue
  • - Volume 2013
  • - Article ID 236081
  • - Research Article

Infection and Coinfection of Human Rhinovirus C in Stem Cell Transplant Recipients

Filippo Canducci | Maurizia Debiaggi | ... | Massimo Clementi
  • Special Issue
  • - Volume 2013
  • - Article ID 347213
  • - Research Article

Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation

Inmaculada Gayoso | Sara Cantisán | ... | Julian Torre-Cisneros
  • Special Issue
  • - Volume 2013
  • - Article ID 926391
  • - Review Article

A Review on JC Virus Infection in Kidney Transplant Recipients

Serena Delbue | Mariano Ferraresso | ... | Pasquale Ferrante
  • Special Issue
  • - Volume 2012
  • - Article ID 543085
  • - Research Article

Variable EBV DNA Load Distributions and Heterogeneous EBV mRNA Expression Patterns in the Circulation of Solid Organ versus Stem Cell Transplant Recipients

A. E. Greijer | S. J. Stevens | ... | J. M. Middeldorp
  • Special Issue
  • - Volume 2012
  • - Article ID 451059
  • - Clinical Study

Validation of Cytomegalovirus Immune Competence Assays for the Characterization of CD8+ T Cell Responses Posttransplant

Eugene V. Ravkov | Igor Y. Pavlov | ... | Julio C. Delgado
  • Special Issue
  • - Volume 2012
  • - Article ID 972102
  • - Research Article

Molecular Networks Involved in the Immune Control of BK Polyomavirus

Eva Girmanova | Irena Brabcova | ... | Ondrej Viklicky
Journal of Immunology Research
 Journal metrics
Acceptance rate40%
Submission to final decision91 days
Acceptance to publication32 days
CiteScore3.330
Impact Factor3.404
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