Long-Term Efficacy and Safety of Everolimus-Eluting Stent Implantation in Japanese Patients with Acute Coronary Syndrome: Five-Year Real-World Data from the Tokyo-MD PCI Study
Table 1
Patient and lesion characteristics.
Variable
ACS group
SCAD group
value
Patients (n)
644
1255
Age (years)
70.5 ± 9.9
69.6 ± 9.9
0.050
Age ≥80 years
135 (21.0%)
195 (15.5%)
0.003
Male
461 (71.6%)
945 (75.3%)
0.080
ST-segment elevation myocardial infarction
218 (33.9%)
0
<0.001
Non-ST-segment elevation myocardial infarction
190 (29.5%)
0
<0.001
Unstable angina pectoris
236 (36.6%)
0
<0.001
Stable angina pectoris
0
885 (70.1%)
<0.001
Silent myocardial ischemia
0
370 (29.5%)
<0.001
Current smoker
139 (20.7%)
233 (18.6%)
0.275
Hypertension
469 (72.8%)
922 (73.5%)
0.765
Dyslipidemia
533 (82.8%)
1025 (81.7%)
0.558
Diabetes mellitus
244 (37.9%)
544 (43.3%)
0.022
Chronic kidney disease
Without hemodialysis
129 (20.0%)
200 (15.9%)
0.027
With hemodialysis
24 (3.7%)
102 (8.1%)
<0.001
Cardiogenic shock state at procedure
33 (5.1%)
0
<0.001
Intra-aortic balloon pumping
40 (6.2%)
3 (0.2)
<0.001
Percutaneous cardiopulmonary support
10 (1.6%)
0 (0.0)
<0.001
Left ventricular ejection fraction <35%
48 (7.5%)
57 (4.5%)
0.009
Triple vessel disease
106 (16.5%)
155 (12.4%)
0.014
Peripheral artery disease
50 (7.8%)
140 (11.2%)
0.020
History of stroke
59 (9.2%)
129 (10.3%)
0.440
History of myocardial infarction
156 (24.2%)
419 (33.4%)
<0.001
Previous percutaneous coronary intervention
172 (26.7%)
509 (40.6%)
<0.001
Previous coronary artery bypass grafting
30 (4.7%)
89 (7.1%)
0.038
Medication
Use of aspirin
641 (99.5%)
1251 (99.7%)
0.617
Use of thienopyridine
636 (98.8%)
1229 (97.9%)
0.197
Use of cilostazol
20 (3.1%)
45 (3.6%)
0.586
Use of anticoagulant agent
69 (10.7%)
143 (11.4%)
0.656
Use of statin
509 (79.0%)
985 (78.5%)
0.781
Use of beta-blocker
348 (54.0%)
562 (44.8%)
<0.001
Use of angiotensin-converting enzyme inhibitor
107 (16.6%)
173 (13.8%)
0.100
Use of angiotensin receptor blocker
282 (43.8%)
566 (45.1%)
0.586
Use of proton pump inhibitor
387 (60.1%)
752 (59.9%)
0.942
Coronary lesion location
<0.001
Left anterior descending coronary artery
311 (48.3%)
519 (41.4%)
Left circumflex coronary artery
100 (15.5%)
246 (19.6%)
Right coronary artery
184 (28.6%)
435 (34.7%)
Left main coronary artery
47 (7.3%)
51 (4.1%)
Bypass graft
2 (0.3%)
4 (0.3%)
Type B2/C lesion
509 (79.0%)
982 (78.2%)
0.691
Restenotic lesion
56 (8.7%)
151 (12.0%)
0.027
Chronic total occlusion
24 (3.7%)
121 (9.6%)
<0.001
Ostial lesion
104 (16.1%)
169 (13.5%)
0.115
Bifurcation
160 (24.8%)
301 (24.0%)
0.679
Severe calcification on angiography
130 (20.2%)
275 (21.9%)
0.385
Number of stents used (n)
1.4 ± 0.7
1.4 ± 0.7
0.742
Average stent diameter (mm)
2.98 ± 0.36
2.97 ± 0.36
0.626
Use of 2.5 mm diameter stent
212 (32.9%)
439 (35.0%)
0.370
Total stent length (mm)
29.5 ± 17.4
29.1 ± 17.4
0.737
Total stent length ≥28 mm
193 (30.0%)
375 (29.9%)
0.968
Use of imaging device for stent placement
565 (87.7%)
1224 (97.5%)
<0.001
Initial thrombolysis in myocardial infarction grade flow
<0.001
0
131 (20.3%)
121 (9.6%)
1
49 (1.6%)
9 (0.7%)
2
105 (16.3%)
12 (0.9%)
3
359 (55.7%)
1113 (88.7%)
Final thrombolysis in myocardial infarction grade flow
0.149
0
1 (0.2%)
0
1
5 (0.8%)
3 (0.2%)
2
10 (1.6%)
15 (1.2%)
3
628 (97.6%)
1237 (98.6%)
Note. Data are given as n (%) or as the mean ± standard deviation. ACS: acute coronary syndrome; SCAD: stable coronary artery disease.
