Long-Term Efficacy and Safety of Everolimus-Eluting Stent Implantation in Japanese Patients with Acute Coronary Syndrome: Five-Year Real-World Data from the Tokyo-MD PCI Study

Table 3

Univariate and multivariate analysis for the safety endpoint (the composite of all-cause death or myocardial infarction) at 1 year.

	Univariate Cox proportional hazard model		Multivariate Cox proportional hazard model
	HR (95% CI)	value	HR (95% CI)	value
ACS versus SCAD	2.033 (1.357–3.046)	0.001	1.260 (0.774–2.053)	0.352
Age ≥80 years	2.369 (1.536–3.656)	<0.001	2.145 (1.358–3.386)	0.001
Male	0.732 (0.475–1.130)	0.159
Current smoker	1.260 (0.782–2.032)	0.342
Hypertension	1.201 (0.745–1.937)	0.451
Dyslipidemia	0.459 (0.298–0.708)	<0.001	0.993 (0.486–2.029)	0.985
Diabetes mellitus	1.291 (0.861–1.935)	0.216
Chronic kidney disease without hemodialysis	1.484 (0.921–2.393)	0.105
Chronic kidney disease with hemodialysis	4.658 (2.927–7.499)	<0.001	3.895 (2.124–7.143)	<0.001
Left ventricular ejection fraction <35%	8.352 (5.366–13.002)	<0.001	3.223 (1.913–5.431)	<0.001
Peripheral artery disease	2.009 (1.118–3.396)	0.009	1.261 (0.692–2.299)	0.449
History of stroke	1.608 (0.911–2.837)	0.101
History of myocardial infarction	0.923 (0.590–1.442)	0.724
Previous percutaneous coronary intervention	0.825 (0.535–1.273)	0.384
Previous coronary artery bypass grafting	1.403 (0.680–2.895)	0.360
Triple vessel disease	2.470 (1.527–3.881)	<0.001	1.380 (0.844–2.255)	0.199
Cardiogenic shock status at procedure	28.050 (16.864–46.656)	<0.001	14.228 (6.511–31.090)	<0.001
Left anterior descending coronary artery	0.835 (0.552–1.263)	0.392
Left circumflex coronary artery	0.584 (0.311–1.095)	0.094
Right coronary artery	1.345 (0.889–2.034)	0.161
Left main coronary artery	2.066 (1.039–4.108)	0.038	1.360 (0.560–1.807)	0.360
Type B2/C lesion	1.677 (0.933–3.011)	0.084
Restenotic lesion	0.546 (0.239–1.247)	0.151
Chronic total occlusion	1.119 (0.542–2.309)	0.761
Ostial lesion	2.921 (1.893–4.506)	<0.001	2.605 (1.600–4.239)	<0.001
Bifurcation	1.349 (0.867–2.099)	0.185
Severe calcification on angiography	2.725 (1.808–4.107)	<0.001	1.364 (0.845–2.203)	0.204
Use of 2.5 mm diameter stent	1.378 (0.914–2.077)	0.126
Total stent length ≥28 mm	1.479 (0.976–2.242)	0.065
Use of imaging device for stent placement	0.281 (0.164–0.481)	<0.001	0.765 (0.378–1.547)	0.456
Use of anticoagulant agent	0.937 (0.499–1.757)	0.838
Use of statin	0.429 (0.283–0.652)	<0.001	0.853 (0.419–1.737)	0.662
Use of beta-blocker	0.752 (0.499–1.133)	0.173
Use of angiotensin-converting enzyme inhibitor	0.625 (0.408–0.957)	0.031	0.684 (0.436–1.073)	0.098
Use of angiotensin receptor blocker	1.176 (0.687–2.014)	0.554

Note. ACS: acute coronary syndrome; SCAD: stable coronary artery disease; HR: hazard ratio; CI: confidence interval.