Long-Term Efficacy and Safety of Everolimus-Eluting Stent Implantation in Japanese Patients with Acute Coronary Syndrome: Five-Year Real-World Data from the Tokyo-MD PCI Study

Table 4

Univariate and multivariate analysis for the safety endpoint (the composite of all-cause death or myocardial infarction) from 1 to 5 years.

	Univariate Cox proportional hazard model		Multivariate Cox proportional hazard model
	HR (95% CI)	value	HR (95% CI)	value
ACS versus SCAD	1.058 (0.789–1.418)	0.706
Age ≥80 years	2.192 (1.606–2.992)	<0.001	2.079 (1.511–2.860)	<0.001
Male	1.099 (0.793–1.522)	0.571
Current smoker	0.735 (0.501–1.077)	0.114
Hypertension	1.283 (0.922–1.786)	0.140
Dyslipidemia	0.615 (0.447–0.846)	0.003	0.749 (0.456–1.231)	0.254
Diabetes mellitus	1.189 (0.903–1.564)	0.217
Chronic kidney disease without hemodialysis	1.931 (1.412–2.641)	<0.001	1.747 (1.244–2.454)	0.001
Chronic kidney disease with hemodialysis	3.966 (2.731–5.759)	<0.001	3.000 (1.931–4.661)	<0.001
Left ventricular ejection fraction <35%	2.931 (1.866–4.604)	<0.001	2.158 (1.345–3.464)	<0.001
Peripheral artery disease	2.663 (1.897–3.739)	<0.001	1.992 (1.384–2.868)	<0.001
History of stroke	1.645 (1.110–2.473)	0.013	1.221 (0.815–1.831)	0.333
History of myocardial infarction	1.307 (0.982–1.739)	0.067
Previous percutaneous coronary intervention	1.150 (0.869–1.521)	0.329
Previous coronary artery bypass grafting	1.595 (1.005–2.530)	0.047	0.921 (0.567–1.497)	0.741
Triple vessel disease	1.625 (1.146–2.303)	0.006	1.252 (0.873–1.797)	0.222
Cardiogenic shock status at procedure	4.032 (1.287–12.625)	0.017	2.984 (0.909–9.792)	0.071
Left anterior descending coronary artery	0.742 (0.559–0.985)	0.039	0.777 (0.580–1.041)	0.091
Left circumflex coronary artery	1.175 (0.839–1.645)	0.347
Right coronary artery	1.175 (0.883–1.562)	0.268
Left main coronary artery	1.221 (0.665–2.242)	0.519
Type B2/C lesion	1.622 (1.112–2.365)	0.012	1.444 (0.983–2.121)	0.061
Restenotic lesion	1.095 (0.715–1.676)	0.677
Chronic total occlusion	0.742 (0.423–1.301)	0.297
Ostial lesion	1.139 (0.772–1.678)	0.510
Bifurcation	0.952 (0.688–1.319)	0.769
Severe calcification on angiography	1.888 (1.401–2.544)	<0.001	1.183 (0.852–1.642)	0.315
Use of 2.5 mm diameter stent	0.865 (0.644–1.163)	0.337
Total stent length ≥28 mm	1.096 (0.812–1.478)	0.550
Use of imaging device for stent placement	1.064 (0.564–2.009)	0.848
Use of anticoagulant agent	1.843 (1.309–2.595)	<0.001	1.428 (1.003–2.035)	0.048
Use of statin	0.636 (0.467–0.866)	0.004	0.946 (0.578–1.549)	0.826
Use of beta-blocker	1.038 (0.789–1.365)	0.791
Use of angiotensin-converting enzyme inhibitor	0.903 (0.685–1.190)	0.470
Use of angiotensin receptor blocker	1.084 (0.739–1.588)	0.681

Note. ACS: acute coronary syndrome; SCAD: stable coronary artery disease; HR: hazard ratio; CI: confidence interval.