Hemodynamic and Lesion Characteristics Associated with Discordance between the Instantaneous Wave-Free Ratio and Fractional Flow Reserve
Table 3
Hemodynamic and lesion factors for iFR and FFR in the concordant and discordant groups.
iFR ≤0.89 FFR >0.8 Discordance (n = 42)
iFR ≤0.89 FFR ≤0.8 Both positive (n = 139)
iFR >0.89 FFR >0.8 Both negative (n = 85)
iFR >0.89 FFR ≤0.8 Discordance (n = 38)
p-value
Systolic blood pressure, mmHg
129 ± 22.3
126 ± 23.4
124 ± 26.2
122 ± 22.5
0.52
Diastolic blood pressure, mmHg
62.2 ± 9.6
60.5 ± 13.1
63.6 ± 14.3
65.0 ± 13.9
0.17
Heart rate, beat/min
75.9 ± 14.6
72.9 ± 11.7
69.1 ± 11.9
67.1 ± 11.7
0.002
Rate-pressure product
9822 ± 2660
9186 ± 2367
8604 ± 2311
8166 ± 2062
0.001
CVP, mmHg
7.2 ± 2.6
6.6 ± 3.1
6.4 ± 3.1
6.9 ± 3.2
0.5
PAWP, mmHg
13.4 ± 4.4
13.2 ± 5.9
12.3 ± 4.9
12.0 ± 4.7
0.37
Cardiac index, L/min/m2
3.4 ± 0.9
3.4 ± 1.2
3.1 ± 0.9
2.9 ± 0.6
0.01
RV5 + SV1, mV
3.1 ± 1.2
2.9 ± 1.3
2.7 ± 1.5
2.5 ± 1.8
0.27
Lesion location
LAD, n (%)
21 (50.0)
99 (71.2)
24 (28.2)
22 (57.9)
<.0001
Proximal lesion
14 (33.3)
62 (44.6)
31 (36.5)
17 (44.7)
0.44
Tandem/diffuse lesion
10 (23.8)
51 (36.7)
18 (21.2)
9 (23.7)
0.055
Diameter stenosis, %
59.5 ± 18.3
65.3 ± 17.8
58.2 ± 16.6
65.4 ± 17.3
0.01
Reference diameter, mm
2.71 ± 0.41
2.62 ± 0.44
2.9 ± 0.55
2.7 ± 0.64
0.001
Lesion length, mm
16.2 ± 5.2
20.4 ± 8.4
14.9 ± 4.8
18.6 ± 5.5
<.0001
iFR, instantaneous wave-free ratio; FFR, fractional flow reserve; CVP, central vein pressure; PAWP, pulmonary artery wedge pressure; LAD, left anterior descending artery. Data are expressed as number (percentage) or mean ± SD.
