Hemodynamic and Lesion Characteristics Associated with Discordance between the Instantaneous Wave-Free Ratio and Fractional Flow Reserve

Table 4

Univariate and multivariate analysis to evaluate predictors of discordance between iFR and FFR.

(a)

	Discordance of iFR ≤0.89 and FFR >0.8
	Univariate analysis			Multivariate analysis
	Odds ratio	95% CI	p-value	Odds ratio	95% CI	p-value
Age	1.01	0.98-1.04	0.34
Female sex	3.4	1.68-6.76	0.01	2.84	1.36-5.96	0.01
Diabetes mellitus	1.32	0.66-2.62	0.43
Hypertension	1.14	0.52-2.51	0.75
Hypercholesterolemia	1.14	0.55-2.34	0.72
Hemodialysis	0.87	0.42-1.82	0.71
Smoking	0.49	0.24-1.01	0.05	0.64	0.30-1.37	0.24
Rate-pressure products	1.17‡	1.03-1.33	0.02	1.17‡	1.02-1.34	0.03
Cardiac index	1.10	1.82-1.47	0.52
Lesion located in LAD	0.81	0.42-1.55	0.52
Diameter stenosis	0.89†	0.74-1.08	0.23
Reference diameter	0.92	0.49-1.75	0.80
Lesion length	0.62†	0.37-1.01	0.06	0.57†	0.32-1.02	0.06

(b)

	Discordance of iFR >0.89 and FFR ≤0.8
	Univariate analysis			Multivariate analysis
	Odds ratio	95% CI	p-value	Odds ratio	95% CI	p-value
Age	0.98	0.95-1.02	0.44
Female sex	0.89	0.37-2.12	0.78
Diabetes mellitus	0.50	0.26-1.04	0.06	0.57	0.28-1.16	0.12
Hypertension	0.71	0.33-1.53	0.39
Hypercholesterolemia	1.51	0.69-3.34	0.30
Hemodialysis	0.06	0.01-0.42	0.005	0.07	0.01-0.53	0.01
Smoking	1.11	0.56-2.20	0.44
Rate-pressure products	0.83‡	0.71-0.98	0.02	0.88‡	0.74-1.04	0.13
Cardiac index	0.57	0.35-0.92	0.01	0.80	0.48-1.35	0.38
Lesion located in LAD	1.16	0.59-2.32	0.66
Diameter stenosis	1.11†	0.92-1.35	0.44
Reference diameter	0.87	0.45-1.71	0.69
Lesion length	1.11†	0.70-1.76	0.64

iFR, instantaneous wave-free ratio; FFR, fractional flow reserve; CI, confidence intervals; LAD, left anterior descending artery.
Per increase 1
†Per increase 10
‡Per increase 1000.