Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography

Table 3

Optical coherence tomography analysis.

	ELCA group	Non-ELCA group	p value
	(n = 18)	(n = 24)
Pre-PCI procedure
MLCSA, mm^2	1.37 ± 0.93	1.02 ± 0.31	0.13
MSCSA, mm^2	6.46 ± 2.14	5.80 ± 1.92	0.32
Neointimal CSA, mm^2	5.09 ± 2.16	4.75 ± 1.85	0.60
Percentage of neointimal area, %	77.9 ± 13.2	80.6 ± 6.6	0.44
After ELCA procedure
MLCSA, mm^2	1.63 ± 0.91	N/A
MSCSA, mm^2	6.67 ± 2.19	N/A
Neointimal CSA, mm^2	5.03 ± 2.22	N/A
Percentage of neointimal area, %	74.1 ± 13.5	N/A
After DCB procedure
MLCSA, mm^2	3.85 ± 1.11	3.42 ± 1.14	0.21
MSCSA, mm^2	6.99 ± 2.14	7.17 ± 2.26	0.78
Neointimal CSA, mm^2	3.13 ± 1.44	3.75 ± 1.60	0.19
Percentage of neointimal area, %	43.7 ± 13.2	51.2 ± 10.7	0.04
Follow-up
MLCSA, mm^2	3.07 ± 1.37	3.33 ± 1.18	0.51
MSCSA, mm^2	6.66 ± 1.92	7.44 ± 1.98	0.20
Neointimal CSA, mm^2	3.59 ± 1.91	4.12 ± 1.84	0.36
Percentage of neointimal area, %	52.5 ± 19.4	54.1 ± 15.3	0.75
Changes ELCA and pre PCI
ΔMLCSA, mm^2	0.67 ± 0.42	N/A
ΔMSCSA, mm^2	0.21 ± 0.99	N/A
ΔNeointimal CSA, mm^2	-0.06 ± 1.13	N/A
Changes after PCI and ELCA
ΔMLCSA, mm^2	2.22 ± 1.19	N/A
ΔMSCSA, mm^2	0.32 ± 1.07	N/A
ΔNeointimal CSA, mm^2	-1.90 ± 1.48	N/A
Changes after and pre PCI
ΔMLCSA, mm^2	2.49 ± 1.31	2.33 ± 1.13	0.69
ΔMSCSA, mm^2	0.53 ± 1.38	0.97 ± 1.02	0.26
ΔNeointimal CSA, mm^2	-1.96 ± 1.56	-1.36 ± 0.92	0.16
Changes at follow-up and after PCI
ΔMLCSA, mm^2	-0.89 ± 1.36	-0.09 ± 1.25	0.05
ΔMSCSA, mm^2	-0.49 ± 1.48	0.28 ± 0.78	0.03
ΔNeointimal CSA, mm^2	0.39 ± 1.94	0.37 ± 0.98	0.96
Number of dissections
After PCI	5.8 ± 3.6	9.0 ± 6.9	0.07
Follow-up	0.1 ± 0.3	0.2 ± 0.4	0.24
Changes at follow-up and after PCI	-5.7 ± 3.5	-8.8 ± 6.8	0.09

Continuous variables expressed as mean ± standard deviation; categorical variables, as number (percentage).
ELCA, excimer laser coronary atherectomy; PCI, percutaneous coronary intervention; MLCSA, minimum lumen cross-sectional area; MSCSA, minimum stent cross-sectional area; CSA, cross-sectional area; DCB, drug-coated balloon.