Review Article

Feasibility of Left Atrial Appendage Closure in Atrial Fibrillation Patients with a History of Intracranial Bleeding: A Systematic Review of Observational Studies

Table 3

Type of devices and antithrombotic regimen after device implant.

Author/yearType of devices usedAntithrombotic used after device implantDuration of anticoagulationDuration of antiplatelet

Ajmal/2020WatchmanVKA 11
DOACs 5
1.5DAPT 4.5 mo
ASA lifelong

Fayos-vidal/2020Amplatzer Amulet 7
Amplatzer Cardiac Plug 2
ASA or clopidogrel 5
Not reported 4
N/A6 months single agent

Pouru/2020Watchman 2
Amplatzer Amulet 60
Amplatzer Cardiac Plug 42
VKA 1
DOAC 10
LMWH 23
ASA 72el 4
ASA + clopidogrel 19
ASA + dipyridamole 2
ASA + Plavix + dipyridamole 2
≤14 days in 17 pts (50%)
≤1 month in 31 pts (91%)
Clopidogrel ≤ 1 month in 21 pts
ASA for ≤6 months in 62 pts
After 6 months ASA 28, ASA + dipyridamole 4

Hucker/2019WatchmanVKA 18
DOAC 32
OAC  +  ASA 27 (out of 50 on OAC)
DAPT 12
1.5DAPT 4.5 mo
ASA lifelong

Hutt/2019WatchmanVKA 21 (55%)
DOAC 17 (45%)
1.5DAPT for 4.5 months 15
ASA lifelong

Nielsen-Kudsk/2017Amplatzer Cardiac Plug and Amplatzer AmuletClopidogrel 64 (62.1%)
ASA 36 (31.1%)
None 7 (6.8%)
N/A6 months

Tzikas/2017Amplatzer AmuletDOAC 3, VKA 14
Clopidogrel 10, ASA + LMWH 6, ASA + DOAC 1
ASA + VKA 9, DAPT 22,
ASA84, triple therapy 1, LMWH 24, no treatment 24
Not reportedNot reported

Renou/2017Watchman and Amplatzer Cardiac Plug used; no numbers givenDAPT 1
ASA 43
N/ADAPT 6 months
ASA lifelong

Martínez-Domeño/20172 Amplatzer Amulet
7 Amplatzer Cardiac Plug
5 Plavix, 4 aspirinN/ANot reported

Cru-Gonzal/2017Watchman 24,
Amplatzer Amulet 21
Amlatzer Cardiac Plug 2
DAPT 38
LMWH 2
Clopidogrel 1
ASA 4
1.51.5

Fahmy/2016Watchman 9
Amlatzer Amulet 5
Amlatzer Cardiac Plug 12
DAPT 24
Clopidogrel 1
ASA 1
N/A12 DAPT 1 mo
11 DAPT 3 mo
1 DAPT 6 mo

Horstman/2014Amplatzer Cardiac PlugVKA 1
DAPT 3 mo
3 moDAPT 19
ASA lifelong

VKA: vitamin K antagonist; DOACs: direct oral anticoagulants; ASA: acetylsalicylic acid; LMWH: low molecular weight heparin; DAPT: dual antiplatelet therapy; OAC: oral anticoagulant.