Research Article

Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry

Table 1

Baseline characteristics.

Total (n = 13,172)EES (n = 5,154)BES (n = 3,007)ZES (n = 5,011) value

Demographics
 Age (years)64.0 ± 10.964.0 ± 10.864.0 ± 11.064.1 ± 11.00.621
 Male (n, %)9216/13172 (70.0%)3537/5154 (68.6%)2119/3007 (70.5%)3560/5011 (71.0%)0.023
 Body mass index (kg/m2)24.6 ± 3.224.6 ± 3.224.6 ± 3.324.6 ± 3.10.911
Coexisting condition
 Diabetes mellitus (n, %)4828/13172 (35.9%)1912/5154 (37.1%)1032/3007 (34.3%)1784/5011 (35.6%)0.036
 Hypertension (n, %)8109/13172 (61.6%)3226/5154 (62.6%)1766/3007 (58.7%)3117/5011 (62.2%)0.001
 Dyslipidemia (n, %)7966/13172 (60.5%)2705/5154 (52.5%)2080/3007 (69.2%)3181/5011 (63.5%)<0.001
 Peripheral vascular disease (n, %)259/13172 (2.0%)90/5154 (1.7%)58/3007 (1.9%)111/5011 (2.2%)0.231
 Chronic renal failure (n, %)572/13172 (4.3%)217/5154 (4.2%)121/3007 (4.0%)234/5011 (4.7%)0.326
Cardiac risk factors
 Current smoker (n, %)3936/13172 (29.9%)1573/5154 (30.5%)890/3007 (29.6%)1473/5011 (29.4%)0.431
 Previous myocardial infarction (n, %)739/13172 (5.6%)346/5154 (6.7%)146/3007 (4.9%)247/5011 (4.9%)<0.001
 Previous PCI (n, %)1941/13172 (14.7%)762/5154 (14.8%)401/3007 (13.3%)778/5011 (15.5%)0.027
 Previous coronary artery bypass surgery (n, %)239/13172 (1.8%)95/5154 (1.8%)56/3007 (1.9%)88/5011 (1.8%)0.924
 Family history of coronary artery disease (n, %)789/13172 (6.0%)284/5154 (5.5%)189/3007 (6.3%)316/5011 (6.3%)0.177
 Left ventricular ejection fraction <40% (n, %)746/11267 (6.6%)318/4604 (6.9%)137/2465 (5.6%)291/4198 (6.9%)0.056
Clinical indication of PCI
 STEMI (n, %)1926/13064 (14.7%)717/5122 (14.0%)484/2967 (16.3%)725/4975 (14.6%)0.017
 NSTEMI (n, %)1922/13064 (14.7%)728/5122 (14.2%)463/2967 (15.6%)731/4975 (14.7%)0.234
 Unstable angina (n, %)4385/13064 (33.6%)1772/5122 (34.6%)929/2967 (31.3%)1684/4975 (33.8%)0.009
 Stable angina (n, %)4317/13064 (33.0%)1650/5122 (32.2%)1006/2967 (33.9%)1661/4975 (33.4%)0.240
 Silent ischemia (n, %)514/13064 (3.9%)255/5122 (5.0%)85/2967 (2.9%)174/4975 (3.5%)<0.001
Lesion characteristics
 Left main disease (n, %)820/13172 (6.2%)329/5154 (6.4%)170/3007 (5.7%)321/5011 (6.4%)0.335
 Multiple target lesions (n, %)3872/13172 (29.4%)1542/5154 (29.9%)831/3007 (27.6%)1499/5011 (29.9%)0.055
At least on target lesion with
 Type B2/C lesion (n, %)10301/13172 (78.2%)3905/5154 (75.8%)2395/30007 (79.6%)4001/5011 (79.8%)<0.001
 Bifurcation (n, %)5339/13172 (40.5%)1918/5154 (37.2%)1284/3007 (42.7%)2137/5011 (42.6%)<0.001
 Severe calcification (n, %)1151/13172 (8.7%)437/5154 (8.5%)311/3007 (10.3%)403/5011 (8.0%)0.001
 Tortuosity (>45°) (n, %)2821/13172 (21.4%)1140/5154 (22.1%)600/3007 (20.0%)1081/5011 (21.6%)0.067
 Thrombotic total (n, %)1438/13172 (10.9%)505/5154 (9.8%)375/3007 (12.5%)558/5011 (11.1%)0.001
 ISR as a target lesion (n, %)505/13151 (3.8%)225/5139 (4.4%)105/3007 (3.5%)175/5005 (3.5%)0.037
 Long lesion (≥28 mm) (n, %)3925/13172 (29.8%)1756/5154 (34.1%)547/3007 (18.2%)1622/5011 (32.4%)<0.001
 Small diameter (≤2.75 mm) (n, %)6066/13172 (46.1%)2473/5154 (48.0%)1236/3007 (41.1%)2357/5011 (47.0 %)<0.001
IVUS-guided (n, %)4946/13172 (37.5%)2033/5154 (39.4%)1022/3007 (34.0%)1891/5011 (37.7%)<0.001
Previous treated lesion (n, %)984/13172 (7.5%)404/5154 (7.8%)151/3007 (5.0%)429/5011 (8.6%)<0.001
Side branch treatment (n, %)1176/13172 (8.9%)408/5154 (7.9%)320/3007 (10.6%)448/5011 (8.9%)<0.001
Number of stents1.6 ± 0.91.7 ± 0.91.6 ± 0.91.6 ± 0.9<0.001
Stent average diameter (mm)3.1 ± 0.53.1 ± 0.43.1 ± 0.43.0 ± 0.50.001
Total stent length (mm)38.8 ± 25.739.8 ± 26.134.8 ± 23.440.3 ± 26.4<0.001
Device success (n, %)12949/13170 (98.3%)5074/5152 (98.5%)2947/3007 (98.0%)4928/5011 (98.3%)0.261
Lesion success (n, %)12927/13170 (98.2%)5069/5152 (98.4%)2944/3007 (97.9%)4914/5011 (98.1%)0.244
Procedural success (n, %)12914/13170 (98.1%)5061/5152 (98.2%)2941/3007 (97.8%)4912/5011 (98.0%)0.392
Angiography f/u (n, %)5340/13172 (40.5%)1954/5152 (37.9%)1401/3007 (46.6%)1985/5011 (39.6%)<0.001
Dedicated angiography f/u (n, %)2866/13172 (21.8%)1085/5152 (21.1%)943/3007 (31.4%)838/5011 (16.7%)<0.001
DAPT duration (days)689 ± 373711 ± 375674 ± 374675 ± 371<0.001

Data are mean (±SD). EES = everolimus-eluting stent; BES = biolimus-eluting stent; ZES = zotarolimus-eluting stent; PCI = percutaneous coronary intervention; STEMI = ST-segment elevation myocardial infarction; NSTEMI = non-ST-segment elevation myocardial infarction; ISR = in-stent restenosis; IVUS = intravascular ultrasound; DAPT = dual antiplatelet therapy.