Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry

Table 4

Independent predictors of stent thrombosis in crude population group.

	HR (95% CI)	value
Cumulative stent thrombosis^†
Age ≥65	2.107 (1.261–3.519)	0.004
Chronic renal failure	3.178 (1.621–6.229)	0.001
Previous PCI	2.019 (1.134–3.595)	0.017
Left ventricular ejection fraction <40%	2.255 (1.234–4.121)	0.008
Premature SAPT	2.162 (1.355–3.448)	0.001
Early stent thrombosis (0–30 days)^‡
Age ≥65	3.735 (1.715–8.133)	0.001
Left ventricular ejection fraction <40%	2.393 (1.070–5.355)	0.034
Late stent thrombosis (31 days)^§
Chronic renal failure	4.668 (1.881–11.581)	0.001
Previous PCI	3.967 (1.716–9.172)	0.001
Left ventricular ejection fraction <40%	2.514 (1.001–6.312)	0.050
Type B2/C	7.667 (1.027–57.224)	0.047

^∗Identification of independent predictors was done with Cox proportional hazard regression model, and the variables were presented with multivariable-adjusted HRs, 95% CI, and -values. ^†Variables included in the model are old age, diabetes mellitus, chronic renal failure, previous PCI, previous CABG, left ventricular dysfunction, premature SAPT, STEMI, multiple lesion, American College of Cardiology/American Heart Association B2/C lesions, previous treated lesion, total stent length, and major classification of used stent. ^‡Variables included in the model are old age, diabetes mellitus, chronic renal failure, previous MI, left ventricular dysfunction, STEMI, multiple lesion, American College of Cardiology/American Heart Association B2/C lesions, total stent length, small diameter, and major classification of used stent. ^§Variables included in the model are old age, chronic renal failure, previous MI, previous PCI, left ventricular dysfunction, STEMI, premature SAPT, American College of Cardiology/American Heart Association B2/C lesions, previous treated lesion, long lesion, small diameter, and major classification of used stent. HR = hazard ratio; CI = confidence interval; PCI = percutaneous coronary intervention; SAPT = single antiplatelet agent therapy; STEMI = ST-segment elevation myocardial infarction; MI = myocardial infarction; CABG = coronary artery bypass surgery.