Coronary Microcirculation in Aortic Stenosis: Pathophysiology, Invasive Assessment, and Future Directions

Table 3

Review of ongoing trials of coronary revascularization in severe aortic stenosis.

Study acronym	Trial ID	Status	N	Description	Completion
FAVOR IV-QVAS	NCT03977129	Recruiting	792	Randomized comparison of QFR and angiography-guided revascularization	2022
NOTION-3	NCT03058627	Recruiting	452	Routine FFR-guided complete revascularization with PCI compared with conservative management in TAVI patients	2025
FAITAVI	NCT03360591	Recruiting	320	Comparison of angiography-guided versus physiology-guided PCI of patients with CAD undergoing TAVI	2021
TCW	NCT03424941	Recruiting	328	FFR-guided PCI and TAVI in severe AS and multivessel CAD vs. CABG and SAVR	2021
FORTUNA	NCT03665389	Not yet recruiting	25	Comparison of FFR derived from coronary computed tomography angiography before TAVR and FFR after TAVI	2022
None	NCT03442400	Recruiting	50	Comparison of pre- and post-TAVI iFR/FFR values and assessment of short-term outcomes	2019
TAVI-PCI	NCT04310046	Not yet recruiting	980	Comparison of FFR-guided PCI within 40 days before TAVI or within 40 days after TAVI	2023