Research Article

The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

Table 1

Characteristics of included studies.

Author, country, yearSample sizeStudy designCI-AKI patients numberInclusion criteriaAge, years N/CMale N/CSCr baseline N/C mmol/LCI-AKI criteriaHypertension % N/CDM% N/CCM type

Wybraniec et al., Poland, 2017 [22]95Prospective9Normal sCr64 (52–75)52 (54.4%)70.72 (60.99–82.21)≥50% relative or ≥0.3 mg/dL absolute increase of serum creatinine concentration at 48 h postprocedurally48 (50.4%)17 (17.6%)Iopromide (LOCM) or Iodixanol (IOCM) or Iomeprol (LOCM)
Akdeniz et al., Turkey, 2015 [8]52Nested case-control32Normal sCr67.5 ± 10.1/61.6 ± 9.411(34.4)/12(60.0)79.56(44.2–167.96)An increase in sCr by 0.3 mg/dL from a baseline level according to the KDIGO 2012 AKI criteria-/0.581.3/85Iodixanol
Li et al., China, 2015 [9]145Prospective19eGFR > 15 mL/min/1.73 m266.8 ± 9.991(62.8)70.58 ± 9.9/60.41 ± 14.20An increase of ≥0.5 mg/dl or ≥25% in SCr levels over the baseline 24–48 h after the intravascular injection of contrast medium, without an alternative etiologyNRNRNonionic, low osmolarity contrast agent
Luo et al., China, 2013 [18]42Nested case-control12sCr < 1.5 mg/dL in male/sCr < 1.2 mg/L in female68.4 ± 10.1/64.7 ± 13.25(41.7)/12(40.0)68.76 ± 10.92/66.57 ± 12.89An absolute rise in sCr of ≥0.5 mg/dl (44.2 mmol/l), and/or a ≥25% increase from the baseline within 48 hours58.3/56.7NRNonionic, low osmolarity contrast medium (iopamidol)
Torregrosa et al., Spain, 2015 [19]144Prospective20eGFR > 15 mL/min/1.73 m272 ± 10/62 ± 1316(75)/94(75.8)78.68 ± 21.22/100.78 ± 23.87An increase in sCr ≥ 50 % according to the RIFLE classification systemNRNRNR
Vijayasimha et al., India, 2014 [17]100Prospective12sCr < 1.5 mg/dL in male/sCr < 1.2 mg/Ll in female48.6 ± 1162(62)106.09 ± 15.03An increase in sCr >25% of the baseline level 48 hours after contrastNRNRLow osmolarity contrast (iodizanol or iopromide) medium.
Wang et al., China, 2014 [10]42Prospective14eGFR >15 mL/min/1.73 m260.2 ± 9.5/60.6 ± 8.17(50)/16(57)82.2 ± 18.3/92.0 ± 15.5An increase of ≥0.5 mg/dl or ≥25% in SCr levels over the baseline 24–48 h after the intra- vascular injection of contrast medium, without an alternative etiology64/6014/17A nonionic, low osmolarity contrast agent 844 mOsm/kg
Wang, China, 2013 [21]260Prospective20sCr < 300 mmol/L73.6 ± 8.9/60 ± 7.58(40)/135(56.3)71.31 ± 8.3/65.7 ± 10.3An increase of ≥0.5 mg/dl or ≥25% in SCr levels over the baseline 24–48 h after the intravascular injection of contrast medium, without an alternative etiology50/2015/5a nonionic, low osmolarity contrast agent 600 mOsm/kg
Wang, China, 2014 [20]66Prospective6eGFR < 60 mL/min/1.73 m2NRNRNRAn increase of ≥0.5 mg/dl or ≥25% in SCr levels over the baseline 24–48 h after the intravascular injection of contrast medium, without an alternative etiologyNRNRNR