Safety and Tolerability of Sodium Thiosulfate in Patients with an Acute Coronary Syndrome Undergoing Coronary Angiography: A Dose-Escalation Safety Pilot Study (SAFE-ACS)

Table 2

Outcome parameters.

Outcome	STS dose (grams)
	0	2.5	5	10	12.5	15
Primary endpoint
Dose-limiting toxicity	0	0	0	0	0	0
Secondary endpoints
Anaphylaxis	0	0	0	0	0	0
Vomiting	0	0	0	0	0	0
Nausea
Mild	0	0	0	0	1	0
Moderate	0	1	0	0	1	0
Severe	0	0	0	0	0	0
Peak values, median (IQR)
Peak CK (U/L)	137 (87–227)
Peak CK-MB (U/L)	23 (15–46)
Peak high sensitive troponin T (ng/L)	80 (29–295)

Moderate nausea complaints commenced before STS administration. CK, creatine kinase; CK-MB, creatine kinase-myocardial band; IQR, interquartile range; STS, sodium thiosulfate.