Usefulness of the Hybrid RFR-FFR Approach: Results of a Prospective and Multicenter Analysis of Diagnostic Agreement between RFR and FFR—The RECOPA (REsting Full-Cycle Ratio Comparation versus Fractional Flow Reserve (A Prospective Validation)) Study

Figure 5

Diagnostic-therapeutic algorithm proposal according to a hybrid RFR-FFR strategy. Initially, the RFR will be performed to assess the hemodynamic significance of the coronary lesions to be evaluated. If the RFR value is inferior to 0.86, the lesion will be treated. In case the RFR value is superior to 0.92, the treatment of the lesion will be deferred. In the intermediate RFR values (from 0.86 to 0.92, with both included), the significance of the coronary lesion will be reclassified by determining the FFR. Lesions with FFR values less than or equal to 0.80 will require treatment. In those lesions with FFR values greater than 0.80, the treatment should be deferred.