Real-World Three-Year Clinical Outcomes of Biolimus-Eluting Stents versus Other Contemporary Drug-Eluting Stents in Patients with Acute Myocardial Infarction Patients: Data from the Korea Acute Myocardial Infarction Registry (KAMIR)

Table 1

Baseline clinical, angiographic, and procedural characteristics of acute myocardial infarction patients according to the use of DES type.

Variables	Entire population				IPTW weighted population
	BES (n = 2,020)	ZES (n = 2,446)	EES (n = 5,293)	value	BES (n = 6,036)	ZES (n = 5,795)	EES (n = 7,936)	value
Men	1540 (76.2)	1850 (75.6)	3984 (75.2)	0.687	4588 (76.0)	4403 (75.9)	5994 (75.5)	0.754
Age (years)	63.3 ± 12.5	63.7 ± 12.3	64.1 ± 12.2	0.358	63.9 ± 12.2	64.2 ± 12.2	64.0 ± 12.2	0.245
LVEF (%)	53.1 ± 10.6	52.1 ± 10.6	51.4 ± 10.7	0.022	52.0 ± 10.5	52.2 ± 10.7	51.7 ± 10.6	0.065
BMI (Kg/m^2)	24.0 ± 3.2	24.2 ± 3.1	24.0 ± 3.3	0.144	24.1 ± 3.1	24.1 ± 3.0	24.0 ± 3.2	0.081
STEMI	1043 (51.6)	1291 (52.7)	2772 (52.3)	0.743	3122 (51.7)	3071 (52.9)	4156 (52.3)	0.384
NSTEMI	977 (48.3)	1155 (47.2)	2521 (47.6)		2914 (48.2)	2724 (47)	3780 (47.6)
Hypertension	971 (48.0)	1205 (49.2)	2675 (50.5)	0.148	2886 (47.8)	2878 (49.6)	3945 (49.7)	0.053
Diabetes mellitus	498 (24.6)	704 (28.7)	1500 (28.3)	0.003	1609 (26.6)	1632 (28.1)	2197 (27.6)	0.169
Dyslipidemia	224 (11.0)	299 (12.2)	593 (11.2)	0.364	705 (11.6)	640 (11.0)	874 (11.0)	0.405
Previous stroke	85 (4.2)	118 (4.8)	300 (5.6)	0.029	272 (4.5)	268 (4.6)	408 (5.1)	0.169
Previous HF	21 (1.0)	23 (0.9)	60 (1.1)	0.737	48 (0.7)	63 (1.0)	86 (1.0)	0.168
Previous PCI	104 (5.1)	217 (8.8)	471 (8.8)	<0.001	449 (7.4)	467 (8.0)	667 (8.4)	0.112
Previous CABG	6 (0.2)	8 (0.3)	38 (0.7)	0.024	41 (0.6)	17 (0.2)	48 (0.6)	0.710
Smoking history	1216 (60.1)	1467 (59.9)	3110 (58.7)	0.413	3613 (59.8)	3485 (60.1)	4719 (59.4)	0.721
Current smoker	844 (41.7)	1009 (41.2)	2093 (39.5)	0.139	2478 (41.0)	2340 (40.3)	3199 (40.3)	0.636
Exsmoker	372 (18.4)	458 (18.7)	1017 (19.2)	0.707	1135 (18.8)	1144 (19.7)	1521 (19.1)	0.424
Laboratory findings
HbA1c (%)	6.4 ± 1.4	6.5 ± 1.4	6.5 ± 1.5	<0.001	6.3 ± 1.3	6.4 ± 1.4	6.4 ± 1.4	0.088
TC (mg/dL)	181 ± 44	182 ± 44	179 ± 45	0.389	179 ± 42	180 ± 43	180 ± 44	0.457
LDL (mg/dL)	115 ± 37	114 ± 39	114 ± 39	0.854	114 ± 37	114 ± 39	114 ± 38	0.514
Discharge medication
Aspirin	1995 (98.7)	2409 (98.4)	5175 (97.7)	0.007	5944 (98.4)	5699 (98.3)	7776 (97.9)	0.070
Clopidogrel	1351 (66.8)	1723 (70.4)	3533 (66.7)	0.004	4028 (66.7)	3967 (68.4)	5350 (67.4)	0.134
Cilostazol	198 (9.8)	255 (10.4)	503 (9.5)	0.447	589 (9.7)	620 (10.6)	778 (9.8)	0.150
Prasugrel	280 (13.8)	244 (9.9)	520 (9.8)	<0.001	686 (11.3)	581 (10.0)	815 (10.2)	0.037
Ticagrelor	359 (17.7)	440 (17.9)	1114 (21.0)	<0.001	1189 (19.7)	1139 (19.6)	1596 (20.1)	0.755
CCB	100 (4.9)	154 (6.2)	308 (5.8)	0.152	307 (5.0)	341 (5.8)	463 (5.8)	0.096
Beta blockers	1713 (84.8)	2092 (85.5)	4473 (84.5)	0.509	5127 (84.9)	4941 (85.2)	6724 (84.7)	0.687
ACEI or ARB	1636 (80.9)	1962 (80.2)	4241 (80.1)	0.698	4786 (79.3)	4686 (80.8)	6388 (80.4)	0.080
Statins	1889 (93.5)	2297 (93.9)	4891 (92.4)	0.033	5616 (93.0)	5453 (94.0)	7364 (92.7)	0.420
Angiographic and procedural characteristics
Treated artery
LAD	1161 (57.4)	1437 (58.7)	3217 (60.7)	0.023	3594 (59.5)	3450 (59.5)	4761 (59.9)	0.816
LCX	559 (27.6)	651 (26.6)	1459 (27.5)	0.639	1611 (26.6)	1547 (26.6)	2176 (27.4)	0.534
RCA	762 (37.7)	1043 (42.6)	2166 (40.9)	0.003	2437 (40.3)	2463 (42.5)	3246 (40.9)	0.050
LM	72 (3.5)	128 (5.2)	287 (5.4)	0.004	256 (4.2)	271 (4.6)	396 (4.9)	0.116
MVD	877 (43.4)	1304 (53.3)	2860 (54.0)	<0.001	3003 (49.7)	3018 (52.0)	4131 (52.0)	0.011
Stent number	1.58 ± 0.73	1.73 ± 0.77	1.75 ± 0.78	<0.001	1.68 ± 0.77	1.71 ± 0.77	1.72 ± 0.77	0.047
Stent D (mm)	3.12 ± 0.40	3.13 ± 0.42	3.11 ± 0.42	0.104	3.12 ± 0.42	3.13 ± 0.42	3.12 ± 0.41	0.436
Stent L (mm)	21.8 ± 9.6	25.1 ± 12.4	27.3 ± 13.2	0.007	24.9 ± 12.6	24.5 ± 12.5	25.9 ± 12.7	0.001

IPTW, inverse probability of treatment weighting; BES, biolimus-eluting stent; EES, everolimus-eluting stent; ZES, zotarolimus-eluting stent; LVEF, left ventricular ejection fraction; BMI, body mass index; STEMI, ST-elevation myocardial infarction; NSTEMI, non-ST-elevation myocardial infarction; HF, heart failure; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft; TC, total cholesterol; LDL, low-density lipoprotein; CCB, calcium channel blocker; ACEI, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; LAD, left anterior descending coronary artery; LCX, left circumflex coronary artery; RCA, right coronary artery; LM, left main artery; D, diameter; L, length.