Journal of Interventional Cardiology / 2021 / Article / Tab 2 / Research Article
High-Dose Atorvastatin Raises Threshold of Contrast-Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention: A Randomized Controlled Study Table 2 Demographic, clinical, echocardiographic, and laboratory data of the two groups.
Parameter Placebo group Statin group valueAge in years (mean ± SD) 59.3 ± 7.1 58.3 ± 8.5 0.4 Sex, males (%) 47 (47) 47 (47) 1.0 Smokers (%) 19 (19) 20 (20) 0.6 HTN (%) 38 (38) 39 (39) 0.9 Previous PCI (%) 4 (4) 4 (4) 1.0 Duration of DM in years (mean ± SD) 7.0 ± 3.5 7.1 ± 4.2 0.8 Insulin therapy (%) 53 (53) 42 (42) 0.1 Heart failure (%) 24 (24) 20 (20) 0.5 Body mass index (mean ± SD) 27.2 ± 3.1 27.2 ± 3.4 1.0 Heart rate in beats/min. (mean ± SD) 84.6 ± 14.8 84.4 ± 14.3 0.9 Systolic blood pressure in mmHg (mean ± SD) 131.9 ± 18.0 134.0 ± 19.5 0.4 Diastolic blood pressure in mmHg (mean ± SD) 83.4 ± 10.6 84.4 ± 10.3 0.5 Segmental wall motion abnormalities (%) 33 (33) 35 (35) 0.8 EF (%) (mean ± SD) 59.7 ± 9.8 59.0 ± 9.8 0.6 Volume of contrast in ml (mean ± SD) 123.0 ± 49.1 119.8 ± 47.6 0.6 Time of X-ray exposure in min. (mean ± SD) 12.1 ± 5.6 11.9 ± 5.4 0.8 Coronary procedure PCI with one stent (%) 63 (63) 70 (70) 0.3 PCI with two stents (%) 31 (31) 22 (22) PCI with > two stents (%) 6 (6) 8 (8) TIMI flow TIMI I (%) 2 (2) 0 (0) 0.3 TIMI II (%) 5 (5) 4 (4) TIMI III (%) 93 (93) 96 (96) Baseline serum creatinine in umol/L (mean ± SD) 1.191 ± 0.17 1.190 ± 0.16 0.9 Follow-up serum creatinine in umol/L (mean ± SD) 1.4 ± 0.3 1.3 ± 0.2 0.02 Hemoglobin in mg/dL (mean ± SD) 12.7 ± 1.8 11.8 ± 1.3 0.1 CIN (%) 18 (18) 6 (6) 0.0001
Statistically significant.