High-Dose Atorvastatin Raises Threshold of Contrast-Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary Intervention: A Randomized Controlled Study

Table 4

Demographic, clinical, echocardiographic, and laboratory data of the two groups.

Parameter	Group A, n = 176	Group B, n = 24	value
Age in years (mean ± SD)	58.8 ± 7.7	58.9 ± 8.3	0.9
Sex, males (%)	80 (45.5)	14 (58.3)	0.1
Smokers (%)	32 (18.2)	7 (29.2)	0.2
HTN (%)	68 (38.6)	9 (37.5)	0.5
Previous PCI (%)	4 (2.3)	4 (16.7)	0.008
Duration of DM in years (mean ± SD)	7.2 ± 4.0	5.9 ± 2.0	0.1
Insulin therapy (%)	81 (46)	14 (58.3)	0.2
Heart failure (%)	29 (16.5)	15 (62.5)	0.001
Body mass index (mean ± SD)	27.1 ± 3.3	27.3 ± 3.3	0.8
Heart rate in beats/min. (mean ± SD)	83.8 ± 14.3	90.0 ± 15.7	0.047
Systolic blood pressure in mmHg (mean ± SD)	132.6 ± 18.9	135.8 ± 17.9	0.4
Diastolic blood pressure in mmHg (mean ± SD)	83.4 ± 10.5	87.9 ± 8.8	0.044
Segmental wall motion abnormalities (%)	54 (30.7)	14 (58.3)	0.007
EF (%) (mean ± SD)	60.0 ± 9.6	54.6 ± 9.7	0.01
Volume of contrast in ml (mean ± SD)	114.2 ± 44.8	174.6 ± 39.7	0.001
Time of X-ray exposure in min. (mean ± SD)	11.2 ± 5.0	18.3 ± 5.5	0.001
Coronary procedure
PCI with one stent (%)	124 (70.5)	9 (37.5)	0.008
PCI with two stents (%)	41 (23.3)	12 (50)
PCI with > two stents (%)	11 (6.2)	3 (12.5)
TIMI flow
TIMI I (%)	0 (0)	2 (8.3)	0.001
TIMI II (%)	2 (1.1)	7 (29.2)
TIMI III (%)	174 (98.8)	15 (62.5)
Hemoglobin in mg/dL (mean ± SD)	12.3 ± 1.6	12.0 ± 1.9	0.3
Statin therapy (%)	94 (53.4)	6 (25)	0.009

Statistically significant.