| | Study, year | Femoral arm, n (%) | Radial arm, n (%) | Mean age (SD) | Male gender (%) | Follow-up length | GP IIb/IIIa in femoral arm, n (%) | Gp IIb\IIIa in radial arm, n (%) | Overall Gp IIb/IIIa use, n (%) | Femoral VCD, n (%) | Major bleeding definition | Study quality |
| | TEMPURA, 2003 | 72 (48.3) | 77 (51.7) | 66 (11) | 121 (81.2) | In hospital | 0 (0.0) | 0 (0.0) | 0.0 | NR | TIMI | 9 | | RADIAL-AMI, 2005 | 25 (50.0) | 25 (50.0) | 55 (12) | 44 (88) | 30 days | 23 (92.0) | 24 (96.0) | 94.0 | 2 (8.0) | Intracranial or intraperitoneal bleeding, a drop in hemoglobin ≥ 5 g/dl or hematocrit ≥ 15% or whole blood or packed red cell transfusions | 8 | | FARMI, 2007 | 57 (50.0) | 57 (50) | 59 (12) | 96 (84.2) | In hospital | 57 (100.0) | 57 (100.0) | 100.0 | 0 (0) | TIMI | 8 | | Yan et al., 2008 | 46 (44.7) | 57 (55.3) | 70.8 (8) | 77 (74.8) | 30 days | 46 (100.0) | 57 (100.0) | 100.0 | 0 (0) | TIMI | 7 | | Gan et al., 2009 | 105 (53.8) | 90 (46.2) | 52.9 (12) | 157 (80.5) | In hospital | 36 (34.3) | 28 (31.1) | 32.8 | 0 (0) | Not specified | 6 | | RADIAMI, 2009 | 50 (50.0) | 50 (50.0) | 59.5 (91.1) | 68 (68) | In hospital | 21 (42.0) | 22 (44.0) | 43.0 | NR | Fatal bleeding, bleeding requiring blood transfusion, operation, or resulting in >3 gr/dl hemoglobin drop, intracranial hemorrhage | 8 | | Hou et al., 2010 | 100 (50.0) | 100 (50.0) | 65.6 (8) | 141 (70.5) | 30 days | 20 (20.0) | 28 (28.0) | 24.0 | 0 (0) | Hemoglobin drop ≥ 2 mmol/l, blood transfusion, need for vascular repair | 6 | | RADIAMI II, 2011 | 59 (54.6) | 49 (45.4) | 59.6 (10) | 69 (64) | In hospital | 32 (54) | 25 (51.0) | 53.0 | 55 (93) | Bleeding resulting in death or needing transfusion or surgical intervention, hemoglobin drop > 3 gr/dl, intercranial bleeding | 8 | | RIVAL, 2012 | 1003 (51.2) | 955 (48.8) | 60 (11) | 1548 (79.1) | 30 days | 312 (31.1) | 329 (34.5) | 32.7 | NR | TIMI and ACUITY | 10 | | RIFLE-STEACS, 2012 | 501 (50.1) | 500 (49.9) | 65 (10) | 734 (73.4) | 30 days | 350 (69.9) | 337 (67.4) | 68.6 | NR | TIMI | 10 | | STEMI-RADIAL, 2014 | 359 (50.8) | 348 (49.2) | 62.1 (11.5) | 546 (77) | 30 days | 162 (45.1) | 155 (45.5) | 44.8 | 136 (38) | HORIZONS-AMI | 10 | | OCEAN RACE, 2014 | 51 (49.5) | 52 (50.5) | 62 (11) | 79 (77) | In hospital | 30 (58.8) | 31 (59.6) | 59.2 | NR | REPLACE-2 | 8 | | MATRIX, 2017 | 2009 (50.1) | 2001 (49.9) | 63.9 (12) | 3093 (77.1) | 30 days | 383 (19.1) | 435 (21.7) | 20.4 | NR | BARC, TIMI, and GUSTO | 10 | | SAFARI-STEMI, 2020 | 1156 (50.4) | 1136 (49.6) | 62 (12) | 1784 (77.8) | 30 days | 68 (5.9) | 69 (6.1) | 6.0 | 789 (68) | TIMI and BARC | 10 |
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