Research Article

Uric Acid to High-Density Lipoprotein Cholesterol Ratio is a Novel Marker to Predict Functionally Significant Coronary Artery Stenosis

Table 1

Baseline demographic and clinical characteristics.

FactorFFR ≤ 0.8 (n = 280)FFR > 0.8 (n = 410)t/χ2/Z

Age (years)57.84 ± 9.7858.91 ± 8.99−1.0340.302
Male (n(%))208 (74.3%)270 (65.9%)5.5580.018
BMI (kg/m2)25.79 ± 2.7725.11 ± 2.712.2380.026
Hypertension (n(%))159 (56.8%)212 (51.7%)1.7260.189
DM (n(%))86 (30.7%)105 (25.6%)2.1660.141
Smoking (n(%))88 (31.4%)124 (30.2%)0.1100.740
HR (bpm)69.85 ± 6.9570.01 ± 6.38−0.2240.823
SBP (mmHg)129.02 ± 8.90127.95 ± 6.981.1390.256
EF (%)64.82 ± 4.7865.14 ± 4.14−0.6500.516
WBC (1012/L)6.30 (5.41,7.66)6.06 (5.05,7.05)−1.9320.053
RBC (1012/L)4.63 ± 0.454.61 ± 0.420.5170.605
PLT (109/L)217.57 ± 45.27220.31 ± 48.02−0.5290.597
MONO (109/L)0.34 (0.27,0.45)0.33 (0.25,0.42)−1.6600.097
LYM (109/L)1.77 (1.42,2.15)1.77 (1.38,2.14)−0.3630.717
NE (109/L)4.01 (3.25,5.02)3.71 (2.96,4.63)−2.1450.032
HG (g/L)142.73 ± 14.67141.38 ± 13.950.8570.392
HCT (%)41.20 ± 3.7240.97 ± 3.610.5680.570
MCV (fl)89.04 ± 3.7989.15 ± 4.17−0.2330.816
MCH (pg)30.85 ± 1.6230.73 ± 1.600.7040.482
MCHC (g/L)346.18 ± 10.69344.37 ± 10.161.5630.119
RDW (fl)42.19 ± 2.5542.14 ± 2.510.1680.867
TG (mmol/L)1.40 (0.99,1.95)1.34 (0.93,1.81)−1.1610.246
TC (mmol/L)4.07 (3.4,4.75)4.03 (3.43,4.90)−0.0230.981
LDL-c (mmol/L)2.38 (1.73,2.97)2.34 (1.77,2.83)−0.5210.602
HDL-c (mmol/L)1.04 (0.92,1.14)1.19 (1.00,1.39)−6.006<0.001
Glu (mmol/L)5.82 (5.27,6.81)5.6 (5.17,6.45)−1.5050.132
HbA1c (mmol/L)5.9 (5.6,6.6)5.8 (5.4,6.5)−1.3840.166
ALT(mmol/L)22 (16,33)21 (15,30)−1.2690.204
AST (mmol/L)21.5 (18,26)21 (18,26)−0.7220.470
TP (g/L)69.64 ± 5.4869.31 ± 5.710.5400.590
ALB (g/L)43.41 ± 3.9143.29 ± 3.950.2750.783
T-bil (μmol/L)13.2 (10.4,16.8)13.2 (10.5,16.5)−0.0260.979
D-bil (μmol/L)2.74 (2.04,3.52)2.87 (2.13,3.79)−0.3380.735
TBA (μmol/L)2.7 (1.4,4.5)2.2 (1.3,3.6)−2.0310.042
ChE(KU/L)8.2 (7.4,9.3)8.3 (7.2,9.2)−0.030.976
GGT (U/L)26 (19,41)26 (18,39)−0.8180.413
ALP (U/L)77 (62,90)78 (66,93)−1.0220.307
Urea (mmol/L)5.2 (4.5,6.2)5.0 (4.3,5.8)−2.0700.038
UA (μmol/L)366.7 (324.8,408.6)310.8 (277.1,358.8)−7.113<0.001
Cr (μmol/L)69.73 ± 13.2065.34 ± 12.163.1340.002
Hcy (μmol/L)11.7 (9.3,15.8)11.9 (8.9,14.8)−0.5910.554
CRP (mg/L)1.00 (0.50,2.08)0.85 (0.39,2.09)−0.9420.346
UHR365.3 (314.6,422.6)268.8 (199.2,345.4)−8.445<0.001
FFR0.75 (0.70,0.78)0.87 (0.84,0.91)−15.636<0.001

Angiography
LM8 (2.9%)12 (2.9%)0.0030.957
LAD230 (82.1%)321 (78.3%)1.5330.261
LCX13 (4.6%)25 (6.1%)0.6770.411
RCA29 (10.4%)52 (12.7%)0.8690.351

Medicine
Aspirin (n(%))270 (96.4%)387 (94.4%)1.5180.218
Statin (n(%))255 (91.1%)368 (89.8%)0.3280.567
UA-lowering drugs (n(%))16 (5.7%)18 (4.4%)0.6230.430
Beta blocker (n(%))171 (61.1%)240 (58.5%)0.4440.505

Abbreviations: BMI, body mass index; DM, diabetes mellitus; HR, heart rate; SBP, systolic blood pressure; EF, ejection fraction; WBC, white blood cell; RBC, red blood cell; PLT, platelet; MONO, monocyte; LYM, lymphocyte; NE, neutrophil; HG, hemoglobin; HCT, hematocrit; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular-hemoglobin concentration; MCV, mean corpuscular volume; RDW, red blood cell distribution width; TG, triglyceride; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; GLu, glucose; HbA1c, glycosylated hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TP, total protein; ALB, albumin; T-Bil, total bilirubin, D-Bil, direct bilirubin; TBA, total bile acid; ChE, cholinesterase; GGT, glutamyl transpeptidase; ALP, alkaline phosphatase; UA, uric acid; Cr, creatinine; Hcy, homocysteine; CRP, C-reactive protein; LM, left main coronary artery; LAD, left anterior descending; LCX, left circumflex; RCA, right coronary artery.