Visceral Abdominal and Subfascial Femoral Adipose Tissue Have Opposite Associations with Liver Fat in Overweight and Obese Premenopausal Caucasian Women
Table 5
Independent contributions (standardized beta coefficients) of metabolic syndrome components to liver-to-spleen ratio, adjusted for age and BMI.
Liver-to-spleen ratio
Percentage of variance explained** (%)
Glucose homeostasis
Fasting insulin, IU/mL
−0.218*
10.1
Fasting glycemia, mg/dL
−0.069
6.6
Hb A1c, %
0.001
6.2
Lipid profile
TC, mg/dL
−0.067
6.5
HDL-C, mg/dL
0.107
7.2
LDL-C, mg/dL
−0.021
6.2
TC/HDL-C ratio
−0.284‡
13.1
LDL-C/HDL-C ratio
−0.181*
9.0
Apo A1/Apo B100 ratio
0.067
6.5
Triglycerides, mg/dL
−0.257†
11.9
Blood pressure
Systolic, mmHg
0.047
6.6
Diastolic, mmHg
0.177*
9.4
Liver enzymes
ALT, IU/L
−0.437‡
24.8
AST, IU/L
−0.346‡
17.8
Inflammation
hs-CRP, mg/dL
−0.006
3.6
Cytokines
IL-6, pg/mL
−0.054
6.1
TNF-, pg/mL
0.013
6.1
Hypercoagulation
PAI-1, ng/mL
−0.208*
9.7
Fibrinogen, mg/dL
−0.011
6.3
Adipokines
Leptin, ng/mL
−0.085
6.8
Adiponectin, ng/mL
0.041
6.4
Urine
Uric acid, mg/dL
−0.178*
8.9
Microalbuminuria, g/min
0.071
6.7
Cortisol, g/day
−0.096
7.1
All variables were entered in the regression models as continuous variables. While age did not present any independent relation to the studied variables, BMI revealed an independent association with all metabolic syndrome features (P < 0.01).
** Variance explained by age, BMI and the studied variable.
*
P < 0.05. †P < 0.01. ‡P < 0.001.
