Protective Effects of Simvastatin, a Lipid Lowering Agent, against Oxidative Damage in Experimental Diabetic Rats

Table 1

In vitro total antioxidant and free radical scavenging activities of simvastatin (SMV), buthylated hydroxyanisole (BHA), and α-tocopherol (α-Toc).

Groups	Total antioxidant activity (Inhibition of lipid peroxidation %)^a	Free radical scavenging activity (DPPH^•μM)^b
α-Toc (80 μg/mL)	46.2	76
BHA (80 μg/mL)	93.7	83
SMV (20 μg/mL)	41.2	38
SMV (40 μg/mL)	60.2	44
SMV (80 μg/mL)	98.3	72

Data are the mean ± SEM for eight animals in each group.
^aThe antioxidant activity of different doses of simvastatin (20–80 μg/mL) was determined by the thiocyanate method. The peroxide values were determined by reading the absorbance at 500 nm after reaction with FeCl₂ and thiocyanate. ^bFree radical scavenging activity of different doses of SMV, BHA, and α-tocopherol by 1,1-diphenyl-2-picrylhydrazyl radicals.