Protective Effects of Simvastatin, a Lipid Lowering Agent, against Oxidative Damage in Experimental Diabetic Rats

Table 2

Effect of simvastatin (SMV) and glibenclamide supplementation on fluid and food intake and body weight of rats in the different experimental groups.

Groups	Fluid intake (mL/day)	Food intake (g/day)	Weight gain (g/day)
Control	28 ± 3	15.3 ± 0.2	4.90 ± 0.03
SMV	33 ± 2	18.2 ± 0.42	4.41 ± 0.06
Diabetic	96 ± 5*	25.7 ± 0.3*	2.96 ± 0.04*
Diabetic + SMV	46 ± 4^*#	22.1 ± 0.5*	3.30 ± 0.05*
Diabetic + Glibenclamide	36 ± 2^*#	23.0 ± 0.2*	3.71 ± 0.03^*#

Data are the mean ± SEM for eight animals in each group.
* 𝑃<0.001 compared with the control group.
^#𝑃<0.05 compared with the untreated diabetic group.