Protective Effects of Simvastatin, a Lipid Lowering Agent, against Oxidative Damage in Experimental Diabetic Rats

Table 4

Effect of simvastatin (SMV) and glibenclamide supplementation on serum total cholesterol, high-density lipoprotein-cholesterol (HDL-C) and triglycerides for rats in different experimental groups.

Groups	Total cholesterol (mg/dL)	HDL-C (mg/dL)	Triglycerides (mg/dL)
Control	77.4 ± 4.4	42.5 ± 1.3	57.3 ± 1.8
SMV	70.8 ± 3.1	44.6 ± 1.6	50.1 ± 2.1
Diabetic	110.3 ± 5.1*	31.2 ± 2.2*	128.6 ± 3.6*
Diabetic + SMV	80.2 ± 2.9^*#	55.7 ± 2.8^*#	61.2 ± 2.4^#
Diabetic + Glibenclamide	89.3 ± 3.6^*#	45.3 ± 1.9^#	68.7 ± 3.6^*#

Data are the mean ± SEM for eight animals in each group.
* 𝑃<0.001 compared with the control group.
^#𝑃<0.05 compared with the untreated diabetic group.