Regulation of Phosphatidic Acid Metabolism by Sphingolipids in the Central Nervous System

Figure 1

Metabolic pathways of sphingolipid metabolism. Ceramide (Cer) is either sinthesized by de novo pathway through the sequential action of serine palmitoyl transferase (SPT), ketosphinganine reductase (3-KR), ceramide synthase (CerS), and dihydroceramide desaturase (DES), or it is generated from sphingomyelin (SM) hydrolisis by sphingomyelinase enzyme (SMase). Cer could be converted into sphingosine (Sph) by ceramidase (CDase) action. Ceramide kinase (CerK) and sphingosine kinase (SphK) generate ceramide 1-phosphate (C1P) and sphingosine 1-phosphate (S1P), respectively.