Regulation of Phosphatidic Acid Metabolism by Sphingolipids in the Central Nervous System
Figure 3
Modulation of PA metabolic pathways by sphingolipids in synaptosomes (Syn) from adult (a) and aged (b) rat cerebral cortex. In adult Syn (a), Cer modulates DAGL and MAGL activities negatively while their phosphorylated form, C1P, stimulates MAG and Gly production via LPAPase/MAGL pathway. In aged Syn (b), results indicate that there is a major modulation by sphingolipids. Cer and Sph stimulate PA metabolization via LPPs/DAGL/MAGL pathway. C1P increases LPAPase, DAGL, and MAGL activities. In contrast, S1P inhibits DAG generation but produces an increase in Gly formation. (1) LPPs, lipid phosphate phosphatase; (2) DAGL, diacylglycerolipase; (3) MAGL, monoacylglycerolipase; (4) PLA, phospholipase A; (5) LPAPase, lysophospholipase phosphatase or LPPs. The relative size of arrows indicates the predominance of PA metabolism pathway.
