Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway
Figure 1
Analysis by surface plasmon resonance spectroscopy of the interaction between C1q and immobilized E-LDL. The E-LDL derivative (14,000 resonance units) was immobilized chemically on the surface of a CM5 sensor chip (GE Healthcare) and allowed to bind to increasing concentrations of soluble C1q (100–600 nM). The value was determined from the ratio of the dissociation and association rate constants () (taken from [14], with permission).
