Lipid Abnormalities and Cardiometabolic Risk in Patients with Overt and Subclinical Thyroid Disease

Table 1

Changes in enzyme activities, transfer proteins, and receptors involved in lipid metabolism induced by thyroid hormones.

Enzymes, transfer proteins, and liver receptors	Thyroid hormone effect
3-hydroxy-3-methyl-glutaryl coenzyme; A reductase	↑
Adipose lipoprotein lipase	Usually normal (may be ↓ in hypothyroidism)
Hepatic lipase	↑
Cholesteryl ester transfer protein	↑
ATP-binding cassette transporter A1	↓
Acetyl-CoA carboxylase 1	↑
Carnitine palmitoyltransferase Ia	↑
7alpha-hydroxylase	↓
LDL receptor	↑