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Journal of Lipids
Volume 2011, Article ID 670479, 8 pages
Research Article

Regulation of Serum Response Factor and Adiponectin by PPAR Agonist Docosahexaenoic Acid

1Donald W. Reynolds Institute on Aging University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot no. 748, Little Rock, AR 72205, USA
2Biology Department, University of Arkansas at Pine Bluff, Pine Bluff, AR 71601, USA
3Central Arkansas Veterans Healthcare System, 4300 West 7th Street, Little Rock, AR 72205, USA

Received 25 March 2010; Revised 18 June 2010; Accepted 3 August 2010

Academic Editor: Michel Lagarde

Copyright © 2011 Clayton Johnson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recent studies indicate that significant health benefits involving the regulation of signaling proteins result from the consumption of omega-3 polyunsaturated fatty acids ( -3 PUFAs). Serum response factor (SRF) is involved in transcriptional regulation of muscle growth and differentiation. SRF levels are increased in the aging heart muscle. It has not been examined whether SRF is made by adipocytes and whether SRF secretion by adipocytes is modulated by PPAR agonist DHA. Adiponectin is made exclusively by adipocytes. We and others have previously reported that PUFAs such as DHA increase adiponectin levels and secretion in adipocytes. Here we show that DHA downregulates SRF with a simultaneous upregulation of adiponectin and that both these responses are reversible by PPAR antagonist. Furthermore, there appears to be a direct relationship between DHA exposure and increased levels of membrane-associated high-density adiponectin, as well as lower levels of membrane-associated SRF. Thus, we find that the levels of SRF and adiponectin are inversely related in response to treatment with PPAR agonist DHA. Decreased levels of SRF along with increase in membrane-associated adiponectin could in part mediate the health benefits of DHA.