Homocysteine as a Risk Factor for Atherosclerosis: Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?

<table>Role of AdoHcy and Hcy in AdoMet-dependent methylation in yeast and mammals. The enzymes involved in yeast and mammalian metabolism are shown in grey circles. AdoMet:  S-adenosyl-L-methionine; AdoHcy:  S-adenosyl-L-homocysteine; Hcy: homocysteine; Met: methionine; CTT: cystathionine; in yeast: Sah1: S-adenosyl-L-homocysteine hydrolase; Sam1 and Sam2: S-adenosyl-L-methionine synthetases; Met6: methionine synthase; Str4: cystathionine β-synthase; Str1: cystathionine γ-lyase; Gsh1: γ-glutamylcysteine synthetase; in mammals: AHCY: S-adenosyl-L-homocysteine hydrolase; MAT: methionine adenosyltransferase; MFMT: 5-methyltetrahydrofolate homocysteine methyltransferase; BHMT: betaine homocysteine methyltransferase; CBS: cystathionine β-synthase; CTH: cystathionine γ-lyase; GSH: glutathione synthase.</table>

Journal of Lipids

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Figure 1

Figure 1: Homocysteine as a Risk Factor for Atherosclerosis: Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?

Figure 1 | Homocysteine as a Risk Factor for Atherosclerosis:  Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism? 