Hydroxyurea Therapy Mobilises Arachidonic Acid from Inner Cell Membrane Aminophospholipids in Patients with Homozygous Sickle Cell Disease
Table 6
Fatty acid composition of red blood cell serine phosphoglycerides of HU-untreated () and treated () HbSS sickle cell patients and HbAA healthy controls ().
Fatty acids
HbSS (untreated)
HbSS (treated)
HbAA (healthy control)
16:0
4.4 ± 0.9
5.5 ± 1.6
5.2 ± 1.2
18:0
41.9 ± 1.3
42.9 ± 1.9
41.6 ± 1.1
20:0
0.3 ± 0.1
0.3 ± 0.06××
0.2 ± 0.07++
22:0
0.1 ± 0.04***
0.2 ± 0.1
0.2 ± 0.07
24:0
tr.
tr.
tr.
∑saturates
46.9 ± 0.9***
49.2 ± 0.8×××
47.5 ± 1.0
16:1n-7
tr.
tr.
tr.
18:1n-7
0.4 ± 0.9***
0.8 ± 0.2
0.7 ± 0.1+++
18:1n-9
4.9 ± 1.03*
6.0 ± 1.23
5.1 ± 1.0
24:1n-9
0.03 ± 0.01***
0.4 ± 0.31
0.3 ± 0.23+++
∑monoenes
5.4 ± 1.1**
7.1 ± 1.5××
5.4 ± 1.2
18:2n-6
3.20 ± 0.6
3.3 ± 0.6×××
6.1 ± 1.6+++
18:3n-6
0.2 ± 0.06***
0.06 ± 0.03×××
0.02 ± 0.02+++
20:2n-6
0.5 ± 0.1***
0.2 ± 0.04
0.3 ± 0.09+++
20:3n-6
3.2 ± 0.8
2.9 ± 0.8×××
2.1 ± 0.3+++
20:4n-6
24.9 ± 2.3**
22.13 ± 2.2×××
25.7 ± 1.9
22:4n-6
6.7 ± 1.1
6.1 ± 1.0×××
3.9 ± 0.8+++
22:5n-6
3.4 ± 0.7**
2.7 ± 0.58××
2.1 ± 0.5+++
∑metabolites
38.8 ± 1.4***
34.1 ± 1.9
33.9 ± 2.4+++
∑n-6
42.0 ± 1.2***
37.0 ± 2.0×××
40.1 ± 2.7++
18:3n-3
tr.
tr.
tr.
20:5n-3
0.07 ± 0.01
0.08 ± 0.09
0.11 ± 0.04++
22:5n-3
1.4 ± 0.3
1.2 ± 0.3
1.1 ± 0.2++
22:6n-3
3.0 ± 0.6
2.8 ± 0.8
2.7 ± 0.8
∑metabolites
4.4 ± 0.7
4.1 ± 1.0
3.9 ± 1.1
∑n-3
4.4 ± 0.7
4.1 ± 1.03
3.9 ± 0.1
N6/N3
9.7 ± 1.9
9.7 ± 2.6
11.0 ± 2.9
tr.: trace. HU-untreated versus treated HbSS patients: *, **, ***. HU-untreated HbSS patients versus HbAA healthy controls: +, ++, +++. HU-treated HbSS Patients versus HbAA healthy controls: ×, ××, ×××.
