Sphingosine 1-Phosphate Distribution in Human Plasma: Associations with Lipid Profiles
Figure 1
Analyses of human plasma sphingosine 1-phosphate (S1P) in lipoprotein- and protein-containing fractions. (a): agarose gel electrophoretogram of g/ml plasma sub-fraction from each subject (lanes 2–7) with whole plasma (lane 1) and g/ml plasma subfraction from a representative subject (lane 8) shown for reference. (b): total cholesterol concentration in the lipoprotein- and plasma protein-containing fractions from each subject determined by gas chromatography. (c): association between HDL cholesterol concentration and the percentage of S1P in plasma localized to the lipoprotein-containing fraction. (d): association between total plasma S1P concentration and the S1P concentration in the plasma protein-containing fraction. (e): association between total plasma S1P concentration and the S1P concentration in the ultracentrifugally isolated lipoprotein-containing fraction. (f): association between total plasma S1P concentration and the S1P concentration in the lipoprotein-containing fraction normalized by the HDL cholesterol concentration in the subject.
