Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer
Figure 3
Schematic presentation of the suggested antiapoptotic mechanism of PON2 and PON3. Its ability to prevent mitochondrial formation impacts on both ER stress-induced pathways (via acting on JNK and CHOP) as well as mitochondrial proapoptotic signaling such as cardiolipin peroxidation and cytochrome C release. See text for details. From our current understanding, PON2 is functionally interchangeable with PON3.
