Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer
Table 2
Expression levels of PON3 in various tumor tissues and/or cancer cell cultures. Microarray experiment (array express) listings are according to the Gene Atlas Database. cDNA levels according to [24]. Cell culture expression levels were roughly estimated as relative level comparing to A549, grouped into low, medium, or high.
Tissue (cancer)
cDNA array (fold of normal tissue)
Microarray studies
Cell culture (expression level in cell line)
Kidney
2.2
Downregulated in clear cell sarcoma of the kidney (E-GEOD-2712/E-TABM-282)
Not detectable (HEK293)
Liver
4.9
Downregulated in hepatocellular carcinoma (HCC) (Choi et al. [21])
High (Huh7) Medium (HepG2)
Lung
3.4
Upregulated in lung adenocarcinoma (E-MTAB-37/E-MTAB-62)
Medium (A549)
Pancreas
3.2
Upregulated in pancreatic carcinoma (E-MTAB-37)
Urinary bladder
3.8
Not detectable (HT1367/RT112)
Esophagus
1.8
Stomach
9.5
Ovar
2.1
Downregulated in ovarian serous papillary carcinomas (OSPCs) (Santin et al. [22])
Cervix
0.5
Downregulated in cervical carcinoma (E-MTAB-62) Upregulated in cervical carcinoma (E-MTAB-37)
Not detectable (HeLa)
Adrenal gland
1.5
Thyroid gland
2.6
Downregulated in papillary thyroid carcinoma (E-GEOD-3467)
Prostate
4.5
Downregulated in prostate carcinoma (E-MTAB-62)
Testis
5.3
Not detectable (SuSa/GCT27/833K)
Uterus/endometrium
16.2
Lymphoid tissue
2.3
Leukemias (various)
n/a
Not detectable in AML-like Nalm6; Jurkat Tcells; PML-like HL60/HCW2 blast crisis line K562; CML-like lama; AML-like THP1 high in CML-like KCL
