Table 4: Hepatic expression of genes related to LCFA uptake, lipogenesis, TG synthesis, lipoprotein synthesis, and transcription regulation in mice fed control or the control supplemented with trans-10, cis-12-CLA. There were no significant interactions of treatment × time. Therefore, the results are presented according to main effects (treatment and time).

GeneTreatmentTimeSEM
ControlCLAWeek 2Week 6

Fatty acid uptake
Cd36−1.47a1.11b−0.01−0.350.55
Slc27a2−0.23−0.04−0.07−0.200.18
De novo synthesis and desaturation
Acaca0.22a0.72b0.420.510.11
Scd−0.92a0.05b−0.50−0.370.19
TG and lipid droplet synthesis
Dgat1−0.020.300.230.050.17
Dgat20.030.250.260.020.15
Gpam−0.31a0.44b0.130.0040.17
Pck1−1.74a−0.29b−0.80−1.240.62
Plin2−0.43a0.40b−0.01−0.020.18
Transcription regulation
Chrebp−0.22−0.17−0.19−0.190.08
Srebf1−0.22a0.14 b0.04−0.110.11
VLDL synthesis
Apob−0.33−0.05−0.09−0.290.19
Cideb−1.13a−0.04b−0.35−0.810.50
Mttp−0.37a0.14b0.002−0.220.17
Carbohydrate Metabolism
Gck−0.45−0.49−0.31−0.630.28
Pc−0.31−0.08−0.08−0.320.28
Slc2a1−0.070.210.18−0.040.14
Lipolysis
Lipc−0.95−0.20−0.15−1.000.54
Pnpla2−0.040.140.24−0.130.24

a,bMeans within each main effect (treatment and time) with different superscripts differ ( 𝑃 0 . 0 5 ).
SEM: the largest standard error of the mean is shown.