Association of RXR-Gamma Gene Variants with Familial Combined Hyperlipidemia: Genotype and Haplotype Analysis
Table 2
Genotype and allele frequencies of individual SNPs within RXR-gamma gene in FCHL probands and controls.
SNPs
Controls ()
Probands ()
Fisher’s
OR (95% CI)
All affected ()
Fisher’s
rs1128977
()
()
()
C25464C
40 (0.41)
25 (0.36)
1.28
0.53
68 (0.38)
0.17
C25464T
40 (0.41)
35 (0.50)
90 (0.51)
T25464T
17 (0.18)
10 (0.14)
19 (0.11)
Allele C
120 (0.62)
85 (0.61)
0.04
0.83
0.95 (0.61–1.49)
226 (0.64)
0.64
Allele T
74 (0.38)
55 (0.39)
128 (0.36)
rs2651860
()
()
()
T33538T
37 (0.35)
37 (0.51)
5.47
0.24
*
85 (0.45)
0.23
*
T33538G
40 (0.38)
17 (0.23)
46 (0.25)
G33538G
29 (0.27)
19 (0.26)
57 (0.30)
Allele T
114 (0.54)
91 (0.62)
2.59
0.11
0.70 (0.46–1.08)
216 (0.57)
0.39
Allele G
98 (0.46)
55 (0.38)
160 (0.43)
rs2134095
()
()
()
T37041T
59 (0.56)
46 (0.62)
0.83
0.66
114 (0.60)
0.58
T37041C
41 (0.39)
25 (0.34)
62 (0.33)
C37041C
6 (0.06)
3 (0.04)
13 (0.07)
Allele T
159 (0.75)
117 (0.79)
0.80
0.37
0.79 (0.48–1.31)
290 (0.77)
0.64
Allele C
53 (0.25)
31 (0.21)
88 (0.23)
rs283696
()
()
()
G38550G
72 (0.62)
35 (0.48)
5.08
0.08
88 (0.48)
0.05
*
G38550A
38 (0.33)
29 (0.40)
68 (0.37)
A38550A
6 (0.05)
9 (0.12)
27 (0.15)
Allele G
182 (0.78)
99 (0.68)
5.32
0.1
*
1.73 (1.08–2.76)
244 (0.67)
0.01
Allele A
50 (0.22)
47 (0.32)
122 (0.33)
rs10918169
()
()
()
G44118G
9 (0.08)
9 (0.12)
2.77
0.25
21 (0.12)
0.13
G44118C
38 (0.32)
28 (0.39)
65 (0.39)
C44118C
71 (0.60)
35 (0.49)
82 (0.49)
Allele G
56 (0.24)
46 (0.32)
3.07
0.08
0.66 (0.42–1.05)
107 (0.32)
0.15
*
Allele C
180 (0.76)
98 (0.68)
229 (0.68)
All significant ( 0.05–0.02) before correction for multiple comparisons (). RXR-gamma: retinoid X receptor-gamma; OR: odds ratio; SNPs: single nucleotide polymorphisms; FCHL: familial combined hyperlipidemia. The positions are related to NCBI Reference Sequence NC_000001.10 (Homo sapiens chromosome 1, GRCh37.p2 primary reference assembly).
