Journal of Lipids / 2013 / Article / Tab 2

Research Article

Association of RXR-Gamma Gene Variants with Familial Combined Hyperlipidemia: Genotype and Haplotype Analysis

Table 2

Genotype and allele frequencies of individual SNPs within RXR-gamma gene in FCHL probands and controls.

SNPsControls ( )Probands ( ) Fisher’s OR (95% CI)All affected ( )Fisher’s

rs1128977 ( ) ( ) ( )
 C25464C40 (0.41)25 (0.36)1.280.5368 (0.38)0.17
 C25464T40 (0.41)35 (0.50)90 (0.51)
 T25464T17 (0.18)10 (0.14)19 (0.11)
 Allele C120 (0.62)85 (0.61)0.040.830.95 (0.61–1.49)226 (0.64)0.64
 Allele T 74 (0.38)55 (0.39)128 (0.36)
rs2651860 ( ) ( ) ( )
 T33538T37 (0.35)37 (0.51)5.470.24 * 85 (0.45)0.23 *
 T33538G40 (0.38)17 (0.23)46 (0.25)
 G33538G29 (0.27)19 (0.26)57 (0.30)
 Allele T114 (0.54)91 (0.62)2.590.110.70 (0.46–1.08)216 (0.57)0.39
 Allele G 98 (0.46)55 (0.38)160 (0.43)
rs2134095 ( ) ( ) ( )
 T37041T59 (0.56)46 (0.62)0.830.66114 (0.60)0.58
 T37041C41 (0.39)25 (0.34) 62 (0.33)
 C37041C 6 (0.06) 3 (0.04) 13 (0.07)
 Allele T159 (0.75)117 (0.79)0.800.370.79 (0.48–1.31)290 (0.77)0.64
 Allele C 53 (0.25) 31 (0.21) 88 (0.23)
rs283696 ( ) ( ) ( )
 G38550G72 (0.62)35 (0.48)5.080.0888 (0.48)0.05 *
 G38550A38 (0.33)29 (0.40)68 (0.37)
 A38550A 6 (0.05) 9 (0.12)27 (0.15)
 Allele G 182 (0.78) 99 (0.68)5.320.1 * 1.73 (1.08–2.76)244 (0.67)0.01
 Allele A 50 (0.22) 47 (0.32)122 (0.33)
rs10918169 ( ) ( ) ( )
 G44118G 9 (0.08) 9 (0.12)2.770.2521 (0.12)0.13
 G44118C38 (0.32)28 (0.39)65 (0.39)
 C44118C71 (0.60)35 (0.49)82 (0.49)
 Allele G 56 (0.24) 46 (0.32)3.070.080.66 (0.42–1.05)107 (0.32)0.15 *
 Allele C180 (0.76) 98 (0.68)229 (0.68)

All significant ( 0.05–0.02) before correction for multiple comparisons ( ).
RXR-gamma: retinoid X receptor-gamma; OR: odds ratio; SNPs: single nucleotide polymorphisms; FCHL: familial combined hyperlipidemia.
The positions are related to NCBI Reference Sequence NC_000001.10 (Homo sapiens chromosome 1, GRCh37.p2 primary reference assembly).

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