5-Lipoxygenase-Activating Protein as a Modulator of Olanzapine-Induced Lipid Accumulation in Adipocyte

Table 1

Effect of low concentrations of MK-886 in the presence of 50 µM olanzapine on intracellular lipid content.

Treatment (5 days)	Lipid content^a
Olanzapine + Vehicle	8.3 ± 0.20
Olanzapine + 0.1 µM MK-886	7.5 ± 0.15*
Olanzapine + 1.0 µM MK-886	7.3 ± 0.15**
Olanzapine + 3.0 µM MK-886	7.2 ± 0.08**

^aOptical density readings at 520 nm × 10 (mean ± SEM; 𝑛 = 3).
* 𝑃 < 0.05.
** 𝑃 < 0.01.