Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPAR𝜸 Signaling and Inflammation in Murine Mammary Tissue

Table 6

Top terms associated with the “mouse phenotype” and “disease” functions in the liver of mice fed trans-10, cis-12-CLA using the ToppGene suite application.

ID	Name	Source	𝑃 value	Term in query	Term in genome
(A) Upregulated genes
Mouse phenotype
(1) MP:0000388	Absent hair follicle inner root sheath		3.96𝐸−04	2	3
(2) MP:0008114	Abnormal Kupffer cell morphology		6.19𝐸−04	3	15
(3) MP:0008989	Abnormal liver sinusoid Morphology		7.45𝐸−04	4	36
(4) MP:0008248	Abnormal mononuclear phagocyte morphology		9.11𝐸−04	12	365
(5) MP:0002628	Hepatic steatosis		1.12𝐸−03	7	140
Disease
(1) D015211	Zellweger syndrome	CTD	8.67𝐸−06	4	12
(2) 214100	Zellweger syndrome; ZS	OMIM	2.53𝐸−04	3	11
(3) 256000	Leigh syndrome; LS	OMIM	5.45𝐸−04	3	14
(4) D007888	Leigh Disease	CTD	6.75𝐸−04	3	15
(5) 20090112:Sabatti	Other metabolic traits	GWAS	2.15𝐸−03	3	22
(B) Downregulated genes
Mouse phenotype
(1) MP:0005328	Abnormal circulating creatinine level		5.30𝐸−05	9	71
(2) MP:0010011	Ectopic hippocampus pyramidal cells		1.41𝐸−04	3	5
(3) MP:0005311	Abnormal circulating amino acid level		3.29𝐸−04	11	130
(4) MP:0003205	Testicular atrophy		3.35𝐸−04	6	39
(5) MP:0009201	External male genitalia atrophy		6.01𝐸−04	2	2
Disease
(1) 607850	Osteoarthritis susceptibility 3; OS3	OMIM	4.94𝐸−04	2	2
(2) 20090621:Hirschfield	Primary biliary cirrhosis	GWAS	6.99𝐸−03	2	6
(3) D008106	Liver cirrhosis, experimental	CTD	8.05𝐸−03	6	79
(4) C535531	Intervertebral disc disease	CTD	9.64𝐸−03	2	7
(5) 603932	Intervertebral disc disease; IDD	OMIM	9.64𝐸−03	2	7