Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPAR𝜸 Signaling and Inflammation in Murine Mammary Tissue

Table 7

Top pathways affected in the liver of mice fed trans-10, cis-12-CLA determined by gene enrichment analysis using the ToppGene suite application.

ID	Name	Source	𝑃 value	Term in Query	Term in Genome
(A) Upregulated genes
(1) Reactome electron transport chain	Genes involved in electron transport chain	MSigDB: C2.cp-Reactome	8.78𝐸−05	7	75
(2) Reactome glucose regulation of insulin secretion	Genes involved in Glucose Regulation of insulin secretion	MSigDB: C2.cp-Reactome	9.15𝐸−05	10	161
(3) PWY-561	Glyoxylate cycle II	BioCyc	1.58𝐸−04	4	20
(4) hsa01040	Biosynthesis of unsaturated fatty acids	KEGG pathway	2.34𝐸−04	4	22
(5) Reactome host interactions of HIV factors	Genes involved in host interactions of HIV factors	MSigDB: C2.cp-Reactome	2.94𝐸−04	8	120
(B) Downregulated genes
(1) PW:0000028	Alanine and aspartate metabolic	Pathway ontology	1.43𝐸−03	3	10
(2) hsa00643	Styrene degradation	KEGG pathway	1.68𝐸−03	2	3
(3) BioCarta eryth pathway	Erythrocyte differentiation Pathway	MSigDB: C2.cp-BioCarta	4.95𝐸−03	3	15
(4) BioCarta stem pathway	Regulation of hematopoiesis by cytokines	MSigDB: C2.cp-BioCarta	4.95𝐸−03	3	15
(5) TYRFUMCAT pwy	Tyrosine degradation	BioCyc	5.42𝐸−03	2	5