Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPAR Signaling and Inflammation in Murine Mammary Tissue
Table 8
Top terms associated with GO functions in the liver of mice fed trans-10, cis-12-CLA using the ToppGene suite application.
GO category
value
Term in query
Term in genome
(A) Upregulated genes
Molecular function
(1) GO:0016491
Oxidoreductase activity
23
727
(2) GO:0051087
Chaperone binding
6
40
(3) GO:0051082
Unfolded protein binding
8
131
(4) GO:0016462
Pyrophosphatase activity
18
798
(5) GO:0016818
Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
18
801
Biological process
(1) GO:0043436
Oxoacid metabolic process
28
862
(2) GO:0019752
Carboxylic acid metabolic process
28
862
(3) GO:0044248
Cellular catabolic process
38
1,492
(4) GO:0006082
Organic acid metabolic process
28
879
(5) GO:0042180
Cellular ketone metabolic process
28
879
Cellular component
(1) GO:0005739
Mitochondrion
45
1,482
(2) GO:0031966
Mitochondrial membrane
24
476
(3) GO:0005740
Mitochondrial envelope
24
498
(4) GO:0019866
Organelle inner membrane
20
379
(5) GO:0044429
Mitochondrial part
27
709
(B) Downregulated genes
Molecular function
(1) GO:0048037
Cofactor binding
18
277
(2) GO:0016823
Hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
2
2
(3) GO:0016822
Hydrolase activity, acting on acid carbon-carbon bonds
2
2
(4) GO:0030170
Pyridoxal phosphate binding
6
56
(5) GO:0070279
Vitamin B6 binding
6
56
Biological process
(1) GO:0032429
Regulation of phospholipase A2 activity
3
7
(2) GO:0007186
G-protein coupled receptor signaling pathway
38
1,008
(3) GO:0007156
Homophilic cell adhesion
10
141
(4) GO:0007205
Protein kinase C-activating G-protein coupled receptor signaling pathway