Trans-10, cis 12-Conjugated Linoleic Acid-Induced Milk Fat Depression Is Associated with Inhibition of PPAR𝜸 Signaling and Inflammation in Murine Mammary Tissue

Table 8

Top terms associated with GO functions in the liver of mice fed trans-10, cis-12-CLA using the ToppGene suite application.

GO category		𝑃 value	Term in query	Term in genome
(A) Upregulated genes
Molecular function
(1) GO:0016491	Oxidoreductase activity	3.41𝐸−07	23	727
(2) GO:0051087	Chaperone binding	1.85𝐸−06	6	40
(3) GO:0051082	Unfolded protein binding	3.33𝐸−05	8	131
(4) GO:0016462	Pyrophosphatase activity	5.26𝐸−04	18	798
(5) GO:0016818	Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	5.49𝐸−04	18	801
Biological process
(1) GO:0043436	Oxoacid metabolic process	9.17𝐸−09	28	862
(2) GO:0019752	Carboxylic acid metabolic process	9.17𝐸−09	28	862
(3) GO:0044248	Cellular catabolic process	1.20𝐸−08	38	1,492
(4) GO:0006082	Organic acid metabolic process	1.40𝐸−08	28	879
(5) GO:0042180	Cellular ketone metabolic process	1.40𝐸−08	28	879
Cellular component
(1) GO:0005739	Mitochondrion	3.03𝐸−13	45	1,482
(2) GO:0031966	Mitochondrial membrane	1.03𝐸−11	24	476
(3) GO:0005740	Mitochondrial envelope	2.64𝐸−11	24	498
(4) GO:0019866	Organelle inner membrane	2.79𝐸−10	20	379
(5) GO:0044429	Mitochondrial part	2.81𝐸−10	27	709
(B) Downregulated genes
Molecular function
(1) GO:0048037	Cofactor binding	2.69𝐸−05	18	277
(2) GO:0016823	Hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	4.46𝐸−04	2	2
(3) GO:0016822	Hydrolase activity, acting on acid carbon-carbon bonds	4.46𝐸−04	2	2
(4) GO:0030170	Pyridoxal phosphate binding	1.15𝐸−03	6	56
(5) GO:0070279	Vitamin B6 binding	1.15𝐸−03	6	56
Biological process
(1) GO:0032429	Regulation of phospholipase A2 activity	3.27𝐸−04	3	7
(2) GO:0007186	G-protein coupled receptor signaling pathway	6.04𝐸−04	38	1,008
(3) GO:0007156	Homophilic cell adhesion	9.83𝐸−04	10	141
(4) GO:0007205	Protein kinase C-activating G-protein coupled receptor signaling pathway	1.27𝐸−03	5	38
(5) GO:0009566	Fertilization	1.45𝐸−03	8	100
Cellular component
(1) GO:0009986	Cell surface	1.94𝐸−04	23	472
(2) GO:0030136	Clathrin-coated vesicle	4.64𝐸−04	12	180
(3) GO:0045202	Synapse	5.01𝐸−04	22	473
(4) GO:0044456	Synapse part	9.17𝐸−04	17	338
(5) GO:0042734	Presynaptic membrane	1.15𝐸−03	6	56