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Journal of Lipids
Volume 2014 (2014), Article ID 686791, 8 pages
http://dx.doi.org/10.1155/2014/686791
Research Article

Association of High Density Lipoprotein with Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios in Coronary Artery Disease Patients

1Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Ahmedabad, Gujarat 380016, India
2Department of Research, U. N. Mehta Institute of Cardiology and Research Centre, Civil Hospital Campus, Ahmedabad, Gujarat 380016, India

Received 31 July 2014; Accepted 20 October 2014; Published 16 November 2014

Academic Editor: Xian-Cheng Jiang

Copyright © 2014 Jayesh H. Prajapati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. We aimed to evaluate a relationship between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) with high density lipoprotein (HDL) cholesterol levels in coronary artery disease (CAD) patients. Methods. A total of 354 patients with angiographically confirmed coronary blockages were enrolled in the study. Hematological indices and lipid profiling data of all the patients were collected. Results. We have observed significant association between HDL and PLR () and NLR (); however no significant relationship was obtained with HDL and isolated platelet (), neutrophil (), and lymphocyte () counts in CAD patients. The association was subjected to gender specific variation as in males PLR () and NLR () were highly elevated in low HDL patients, whereas in females the elevation could not reach the statistically significant level. The PLR (217.47 versus 190.3; ) and NLR (6.33 versus 5.10; ) were significantly higher among the patients with acute coronary syndrome. In young patients the PLR () and NLR () were inversely associated with HDL, whereas in older population only NLR () had showed a significant association. Conclusion. We conclude that PLR and NLR are significantly elevated in CAD patients having low HDL levels.