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Journal of Lipids
Volume 2015 (2015), Article ID 496169, 18 pages
http://dx.doi.org/10.1155/2015/496169
Review Article

Beneficial Role of Bitter Melon Supplementation in Obesity and Related Complications in Metabolic Syndrome

1Department of Pharmaceutical Sciences, North South University, Dhaka 1229, Bangladesh
2Department of Pharmacy, Stamford University Bangladesh, Dhaka 1217, Bangladesh
3School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia

Received 30 August 2014; Accepted 5 December 2014

Academic Editor: Xian-Cheng Jiang

Copyright © 2015 Md Ashraful Alam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in daily food in Bangladesh and several other countries in Asia. The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro. Recent scientific evaluation of this plant extracts also showed potential therapeutic benefit in diabetes and obesity related metabolic dysfunction in experimental animals and clinical studies. These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth. This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.