Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality
Table 3
Lipid-lipoprotein profile according to apolipoprotein E genotype and abdominal obesity.
ApoE 2/4 (A)
ApoE 2/2 (B)
ApoE 2/3 (C)
ApoE 3/3 (D)
ApoE 3/4 (E)
ApoE 4/4 (F)
ANOVAs or KW
ANOVAs or KW
Nonobese/obese
51/53
32/62
268/388
560/725
228/258
28/27
value
value
Triglycerides
Nonobese
1.76 ± 1.65
2.24 ± 2.34
1.45 ± 1.75
1.26 ± 1.75
1.46 ± 1.41
1.56 ± 1.11
<0.001
<0.001
Obese
2.41 ± 2.15
3.44 ± 3.54
2.25 ± 2.11
1.93 ± 2.09
2.18 ± 2.60
3.14 ± 4.43
<0.001
<0.001
LDL-cholesterol1
Nonobese
3.32 ± 0.93
2.86 ± 0.85
3.27 ± 0.84
3.45 ± 0.82
3.53 ± 1.71
<0.001
<0.001
Obese
3.28 ± 0.85
2.97 ± 1.07
3.27 ± 0.90
3.48 ± 0.81
3.51 ± 0.84
3.56 ± 0.98
<0.001
<0.001
HDL-cholesterol1
Nonobese
1.32 ± 0.51
1.39 ± 0.75
1.38 ± 0.49
1.38 ± 0.43
1.35 ± 0.44
1.39 ± 0.30
NS
NS
Obese
1.03 ± 0.29
1.00 ± 0.35
1.10 ± 0.36
1.10 ± 0.36
1.06 ± 0.36
0.88 ± 0.36
0.006
<0.001
VLDL-cholesterol
Nonobese
0.66 ± 1.17
1.41 ± 2.21
0.60 ± 0.72
0.43 ± 0.60
0.56 ± 0.76
0.67 ± 0.53
<0.001
<0.001
Obese
0.95 ± 0.70
2.28 ± 2.27
1.01 ± 1.19
0.76 ± 0.71
0.88 ± 1.16
1.27 ± 1.45
<0.001
<0.001
VLDL-triglycerides
Nonobese
0.99 ± 1.32
1.67 ± 2.64
0.87 ± 1.19
0.68 ± 1.14
0.93 ± 1.38
1.05 ± 1.02
<0.001
<0.001
Obese
1.57 ± 1.62
2.15 ± 1.87
1.61 ± 1.94
1.31 ± 1.36
1.58 ± 2.56
2.23 ± 3.13
<0.001
<0.001
Non-HDL-cholesterol1,†
Nonobese
4.18 ± 1.60
3.81 ± 3.01
3.54 ± 1.34
3.83 ± 1.04
4.15 ± 1.17
4.28 ± 0.98
<0.001
<0.001
Obese
4.44 ± 1.06
5.80 ± 3.48
4.52 ± 1.43
4.42 ± 1.10
4.62 ± 1.30
5.46 ± 1.25
<0.001
<0.001
Total cholesterol/HDL-cholesterol
Nonobese
4.50 ± 2.51
4.70 ± 24.28
3.81 ± 2.75
3.97 ± 1.62
4.33 ± 1.99
4.19 ± 1.38
<0.001
<0.001
Obese
5.54 ± 1.91
7.42 ± 8.61
5.45 ± 3.11
5.32 ± 4.53
5.71 ± 3.54
8.11 ± 13.52
<0.001
<0.001
VLDL-cholesterol/triglycerides
Nonobese
0.38 ± 0.15
0.64 ± 0.24
0.40 ± 0.10
0.33 ± 0.10
0.35 ± 0.08
0.38 ± 0.09
<0.001
<0.001
Obese
0.43 ± 0.10
0.78 ± 0.23
0.44 ± 0.10
0.38 ± 0.08
0.38 ± 0.07
0.40 ± 0.07
<0.001
<0.001
Data are mean ± SD and shown when no covariates are included in the models. Note: HDL: high-density lipoprotein; LDL: low-density lipoprotein; non-HDL-cholesterol: cholesterol total − high-density lipoprotein cholesterol; VLDL: very-low-density lipoprotein; KW: Kruskal-Wallis tests. 1Units are in mmol/L. Among a subsample of 1,531 subjects. Significantly different () as compared to ; to E2/2; to E2/3; to E3/3; and to E3/4 within the same nonobese/obese group. Significant differences between nonobese and obese subjects within the same genotype group are in italic font. value obtained after log10 transformation of the data; geometric means are shown. †Kruskal-Wallis tests followed by Mann-Whitney U tests; geometric means are shown. When controlled for age, sex, and type 2 diabetes.
