Journal of Lipids / 2015 / Article / Tab 3

Research Article

Influence of Abdominal Obesity on the Lipid-Lipoprotein Profile in Apoprotein E2/4 Carriers: The Effect of an Apparent Duality

Table 3

Lipid-lipoprotein profile according to apolipoprotein E genotype and abdominal obesity.

ApoE 2/4
(A)
ApoE 2/2
(B)
ApoE 2/3
(C)
ApoE 3/3
(D)
ApoE 3/4
(E)
ApoE 4/4
(F)
ANOVAs or KWANOVAs or KW
Nonobese/obese51/5332/62268/388560/725228/25828/27 value value

Triglycerides
 Nonobese1.76 ± 1.652.24 ± 2.341.45 ± 1.751.26 ± 1.751.46 ± 1.411.56 ± 1.11<0.001<0.001
 Obese2.41 ± 2.153.44 ± 3.542.25 ± 2.111.93 ± 2.092.18 ± 2.603.14 ± 4.43<0.001<0.001
LDL-cholesterol1
 Nonobese3.32 ± 0.932.86 ± 0.853.27 ± 0.843.45 ± 0.823.53 ± 1.71<0.001<0.001
 Obese3.28 ± 0.852.97 ± 1.073.27 ± 0.903.48 ± 0.813.51 ± 0.843.56 ± 0.98<0.001<0.001
HDL-cholesterol1
 Nonobese1.32 ± 0.511.39 ± 0.751.38 ± 0.491.38 ± 0.431.35 ± 0.441.39 ± 0.30NSNS
 Obese1.03 ± 0.291.00 ± 0.351.10 ± 0.361.10 ± 0.361.06 ± 0.360.88 ± 0.360.006<0.001
VLDL-cholesterol
 Nonobese0.66 ± 1.171.41 ± 2.210.60 ± 0.720.43 ± 0.600.56 ± 0.760.67 ± 0.53<0.001<0.001
 Obese0.95 ± 0.702.28 ± 2.271.01 ± 1.190.76 ± 0.710.88 ± 1.161.27 ± 1.45<0.001<0.001
VLDL-triglycerides
 Nonobese0.99 ± 1.321.67 ± 2.640.87 ± 1.190.68 ± 1.140.93 ± 1.381.05 ± 1.02<0.001<0.001
 Obese1.57 ± 1.622.15 ± 1.871.61 ± 1.941.31 ± 1.361.58 ± 2.562.23 ± 3.13<0.001<0.001
Non-HDL-cholesterol1,†
 Nonobese4.18 ± 1.603.81 ± 3.013.54 ± 1.343.83 ± 1.044.15 ± 1.174.28 ± 0.98<0.001<0.001
 Obese4.44 ± 1.065.80 ± 3.484.52 ± 1.434.42 ± 1.104.62 ± 1.305.46 ± 1.25<0.001<0.001
Total cholesterol/HDL-cholesterol
 Nonobese4.50 ± 2.514.70 ± 24.283.81 ± 2.753.97 ± 1.624.33 ± 1.994.19 ± 1.38<0.001<0.001
 Obese5.54 ± 1.917.42 ± 8.615.45 ± 3.115.32 ± 4.535.71 ± 3.548.11 ± 13.52<0.001<0.001
VLDL-cholesterol/triglycerides
 Nonobese0.38 ± 0.150.64 ± 0.240.40 ± 0.100.33 ± 0.100.35 ± 0.080.38 ± 0.09<0.001<0.001
 Obese0.43 ± 0.100.78 ± 0.230.44 ± 0.100.38 ± 0.080.38 ± 0.070.40 ± 0.07<0.001<0.001

Data are mean ± SD and shown when no covariates are included in the models.
Note: HDL: high-density lipoprotein; LDL: low-density lipoprotein; non-HDL-cholesterol: cholesterol total − high-density lipoprotein cholesterol; VLDL: very-low-density lipoprotein; KW: Kruskal-Wallis tests.
1Units are in mmol/L.
Among a subsample of 1,531 subjects.
Significantly different () as compared to ; to E2/2; to E2/3; to E3/3; and to E3/4 within the same nonobese/obese group.
Significant differences between nonobese and obese subjects within the same genotype group are in italic font.
value obtained after log10 transformation of the data; geometric means are shown.
Kruskal-Wallis tests followed by Mann-Whitney U tests; geometric means are shown.
When controlled for age, sex, and type 2 diabetes.

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