Cholesterol Efflux Capacity of Apolipoprotein A-I Varies with the Extent of Differentiation and Foam Cell Formation of THP-1 Cells

Figure 5

The effect of foam cell formation on cholesterol efflux capacity of apoA-I. After PMA treatment for 2 days, cells were loaded with ³H-cholesterol (1 μCi/mL), acLDL (50 μg protein/mL), and T0901317 (1 μmol/L) for 1 to 5 days. Under these conditions, the cholesterol efflux capacity was determined. The values were indicated by mean + SD ( = 3, < 0.05 versus day 1, < 0.05 versus day 2, < 0.05 versus day 3, and < 0.05 versus day 3).