Research Article

Elucidation of the Role of Lectin-Like oxLDL Receptor-1 in the Metabolic Responses of Macrophages to Human oxLDL

Table 4

Extracellular acidification rates of various LDL exposure to macrophages. Mean peak MAMP height changes and standard errors for each experimental condition during exposure. All values are calculated based on peak height versus 10 min average basal value prior to exposure. Terms in bold are representative of , indicating statistical significance.

Acidification
Native LDL (%)Low oxLDL (%)Medium oxLDL (%)High oxLDL (%)Intracel oxLDL (%)

1 µg/ml0.73 ± 1.68.1 ± 3.31.03 ± 4.72.13 ± 1.72.13 ± 1.8
= 0.7001 = 0.0918 = 0.8452 = 0.268 = 0.3317
10 µg/ml1.2 ± 2.48.28 ± 6.64.53 ± 8.43.61 ± 4.828.5 ± 22.4
= 0.6481 = 0.4708 = 0.6254 = 0.4864 = 0.3044
50 µg/ml5.8 ± 5.21.12 ± 1.962.8 ± 0.6013.1 ± 11.346.8 ± 23.6
= 0.3156 = 0.6205p = 0.025 = 0.3280 = 0.1044
100 µg/ml25.6 ± 2.41.3 ± 0.13.1 ± 5.221.6 ± 10.622.0 ± 2.7
p = 0.0018p < 0.0001 = 0.8183 = 0.2628p = 0.0005